Senolytic Drugs Show Promise Against Bone Loss Caused by Chemotherapy
A new mouse study shows that senolytic drugs targeting senescent cells can partially mitigate the bone loss and marrow fat ...
Tag: senolytics
Vascular Receptor TLR4 Emerges as a Master Switch Between Vascular Aging and Targeted Senotherapeutics
A new review in Aging Cell positions endothelial TLR4 as a context-dependent molecular rheostat controlling vascular senescence, arguing that precision ...
Engineered Flavonoid Cousins of Fisetin Clear Senescent Cells and Boost Healthspan in Mice
Researchers engineered two fisetin-derived flavonoid analogs that kill senescent cells up to 27 times more potently than fisetin and reduce ...
Better Survival in Mice Is Not Proof of Senolytic Anti-Ageing Success, Researchers Warn
A new letter in the Journal of Translational Medicine argues that a senolytic vaccine study showed real therapeutic benefit in ...
Cellular Senescence Takes Center Stage as ICSA Gathers Global Aging Researchers in Seoul
The journal Aging will support the 11th International Cell Senescence Association Conference, taking place November 3 to 5, 2026, at ...
Failing Cellular Recycling Lets Zombie Cells Pile Up as We Age, Study Finds
A new Nature Aging study from Albert Einstein College of Medicine shows that age-related decline in chaperone-mediated autophagy allows senescent ...
T Cell-Engaging Antibody Clears Aging Cells in Mice and Monkeys, With Liver Enzymes as a Built-In Safety Gauge
A uPAR-targeting bispecific T-cell engager safely cleared senescent cells in aged mice and rhesus macaques, with serum liver enzymes serving ...
Ancient Herb Compound Purges Zombie Cells That Make Arteries Fragile
Researchers report that salvianolic acid A, a compound from Salvia miltiorrhiza, directly binds HSP90α to dismantle the AKT-PERK survival complex ...
Immune Cells as Anti-Aging Weapons? NK Cell Senolytics Face Their First Real Test
A new GeroScience review argues that a patient's own cytokine-primed natural killer cells could serve as cellular senolytics, but insists ...
Scientists Gather in Shanghai to Push Aging Biomarkers Toward Human Intervention Testing
A Nature Aging meeting report describes how the 6th TimePie Longevity Forum in Shanghai brought together international researchers to advance ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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