Tag: senolytics

A uPAR-targeting bispecific T-cell engager safely cleared senescent cells in aged mice and rhesus macaques, with serum liver enzymes serving ...

Researchers report that salvianolic acid A, a compound from Salvia miltiorrhiza, directly binds HSP90α to dismantle the AKT-PERK survival complex ...

A new GeroScience review argues that a patient's own cytokine-primed natural killer cells could serve as cellular senolytics, but insists ...

A Nature Aging meeting report describes how the 6th TimePie Longevity Forum in Shanghai brought together international researchers to advance ...

A new BMC Medicine review explains how chemoradiotherapy can push cervical cancer fibroblasts into a senescent state whose inflammatory secretions ...

A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...

A new review argues that immune aging and manufacturing stress, not just tumor biology, explain why gamma-delta T cell cancer ...

A new review in Cancer Reports details how the senescence-associated secretory phenotype can both suppress and fuel tumors, and how ...

A comprehensive new review details how senescent fibroblasts, macrophages, keratinocytes and stem cells drive skin aging through ROS, DNA damage, ...

Researchers have identified the little-studied transmembrane protein PTCHD4 as a novel regulator of cellular senescence whose deletion extends lifespan and ...