Cellular Recycling Pathway Slows Aging by Keeping Senescent Cells in Check
Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of ...
Tag: senolytics
DNA Damage Response Drives PD-L1 Shield That Lets Aging Cells Evade Immune Clearance
A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...
Sirtuin 1 emerges as the molecular switch linking cellular senescence to heart failure
A new review argues that the longevity enzyme sirtuin 1 sits at the molecular crossroads between cellular senescence and heart ...
Control Theory Offers a New Mathematical Map for Safer Aging Drug Discovery
A new control theory framework published in Aging redefines aging as a progressive loss of safe controllability and proposes safety-first ...
The Aging Kidney Gets a Data-Driven Atlas: Machine Learning and Ferroptosis Lead a New Research Era
A sweeping bibliometric analysis of 2,191 papers reveals that kidney aging research has exploded since 2018, with machine learning, ferroptosis, ...
One Cancer Gene, Two Fates: Study Shows Senescent Cells Split Into Tumor Blockers and Tumor Seeds
An NYU Abu Dhabi study in EMBO Reports shows that a single cancer-causing gene drives liver cells into distinct senescent ...
Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
Experimental Drug SMIP004 Hunts Down Dormant Cancer Cells Left Behind by Chemotherapy
Researchers report that the mitochondria-targeting compound SMIP004 selectively kills therapy-induced senescent cancer cells by promoting degradation of the AMPK-stabilized metabolic ...
Senolytic Drugs and Aerobic Exercise Each Rejuvenate the Aging Mouse Heart
A nine-month study in mice shows that chronic senolytic treatment and aerobic exercise each reduce senescent cell markers in the ...
Anti-ageing drug combo clears senescent cells and reverses liver scarring in first randomized trial
A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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