m6A RNA modification emerges as a key sculptor of the tumor microenvironment
A new open-access review describes how the m6A RNA modification acts as a key determinant in reshaping the tumor microenvironment ...
Tag: RNA modification
NAT10 enzyme drives follicular atresia through ac4C modification of Tnc mRNA
A new study reports that NAT10-catalyzed ac4C modification stabilizes Tnc mRNA, inhibiting mitophagy and driving follicular atresia, with the NAT10 ...
Cell Study Links RNA Modification WTAP to KDR Protection in Aneurysm Model
A cell study finds that WTAP upregulates KDR through m6A modification, protecting human brain microvascular endothelial cells from angiotensin II-induced ...
ZFX Drives T-cell Leukemia Growth Through m5C Methylation of PD1 mRNA
A new study shows that ZFX promotes T-cell acute lymphoblastic leukemia by activating NSUN2-mediated m5C methylation, which stabilizes PD1 mRNA.
RNA Modifications and Metabolism: Decoding Crosstalk in Liver Cancer
RNA modification networks and metabolic reprogramming establish reciprocal circuits that drive hepatocellular carcinoma progression and therapeutic resistance.
WDR4 Gene Variant Linked to Prostate Cancer Risk in Genetic Study
A genetic variant in the RNA-modifying gene WDR4 has been associated with prostate cancer susceptibility in a two-stage genetic association ...
Chemical Tags on RNA May Steer the Course of Aortic Dissection
A new review details how the RNA modification m6A influences cell death, inflammation and risk factors in aortic dissection, pointing ...
RNA Tag m6A Emerges as a Master Switch in Gene Control, Stress and Disease
A review in Nature Reviews Molecular Cell Biology explains how the RNA modification N6-methyladenosine regulates gene expression, enables cellular adaptation, ...
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
Two Molecular Machines, One Cancer Engine: How Deubiquitinases and m6A RNA Tags Talk to Each Other
A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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