Excess ASNS links neuronal stress to Angelman syndrome features in mice
Reducing excess asparagine synthetase in a mouse model of Angelman syndrome restored protein synthesis and improved microcephaly and many behavioural ...
Tag: proteostasis
Cold triggers a muscle-to-tissue metabolic network in worms
A nematode study shows how cold-induced BH2 production in muscle coordinates longevity and protein homeostasis across distant tissues.
Unstressed yeast study links Zuo1 surveillance to predicted protein disorder
A study in unstressed yeast found that loss of the ribosome-associated chaperone Zuo1 allowed transcripts encoding more disordered proteins to ...
Review finds no single cause for apparent cancer–Alzheimer inverse association
A Mini Review finds that modest inverse associations between cancer and Alzheimer’s disease reflect interacting epidemiological, treatment and biological factors ...
Cellular Recycling Pathway Slows Aging by Keeping Senescent Cells in Check
Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of ...
Gut-Brain Homeostatic Continuum: A Systems Framework for Alzheimer’s Disease Resilience and Progression
A new conceptual framework called the Gut-Brain Homeostatic Continuum reframes Alzheimer's disease as a progressive erosion of organismal resilience driven ...
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
Q Fever Bacterium Hijacks Host Protein Recycling Machinery to Build Its Replicative Home
Researchers have discovered that the Q fever bacterium Coxiella burnetii uses a secreted effector protein called CelF to competitively block ...
Molecular Hydrogen Emerges as a Versatile Adjuvant in Cancer Therapy
A new review in Frontiers in Chemical Biology maps how molecular hydrogen reprograms oncogenic signaling, epigenetics, mitochondrial stress, and antitumor ...
Shared Molecular Fingerprint of Alzheimer’s and Lewy Body Dementia Revealed in Human Brain Maps
A whole-transcriptome study of five brain regions from verified Alzheimer's and Lewy body dementia donors reveals a shared molecular signature ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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