Plant Compounds Show Promise Against Toxic Protein Clumps in Brain Disease
A comprehensive review in 3 Biotech details how plant-derived compounds such as polyphenols, flavonoids, and alkaloids can inhibit the toxic ...
Tag: proteostasis
Engineered Protein Breakdown Supercharges Drug-Free Selection of High-Producing CHO Cells
Researchers at Inha University engineered destabilized glutamine synthetase variants that dramatically increase selection stringency in CHO cells, enabling drug-free isolation ...
When Mitochondrial Calcium Goes Wrong, Plants Sound a Whole-Cell Alarm
New research in Arabidopsis shows that disrupting the mitochondrial calcium uniporter triggers a coordinated unfolded protein response spanning the nucleus, ...
How Cells Build Their Protein Shredder: New Rules of Proteasome Biogenesis
A new review argues that mammalian cells regulate the construction of their proteasomes through layered transcriptional networks and assembly pathways, ...
Cell Rest Is Not a Dead End: Threshold Model Reframes Quiescence and Senescence
A new perspective in Molecular Cancer argues that quiescence and senescence are points on a single continuum of arrested states ...
Damiana Plant Polysaccharides Extend Lifespan in Worms and Flies, Study Finds
Polysaccharides from the traditional medicinal plant Turnera diffusa extended lifespan and improved stress resistance in worms and flies by activating ...
Proteasome Inhibition Eases Proteinuria in Mice With Faulty Kidney Filtration Genes
Blocking the proteasome reduces protein leakage in the urine of mice carrying dysfunctional Lmx1b LIM domains, pointing to a new ...
Molecular Efficiency Decides Which Alpine Desert Plants Survive Warming Climates
A multi-year field experiment on the Qinghai-Xizang Plateau reveals that transcriptomic efficiency, not the magnitude of gene expression change, determines ...
Tree Bark Polysaccharides Slow Aging in Worms and Flies Through FOXO and Nrf2 Pathways
Polysaccharides from the African tree Pausinystalia macroceras extended lifespan and healthspan in worms and flies by activating the conserved DAF-16/FOXO ...
One Amino Acid Decides Whether Mitochondria Keep Their Protein Machines Intact
A single N-terminal amino acid removed during mitochondrial protein maturation globally stabilizes the organelle's protein complexes, revealing a new layer ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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