Retina’s Electrical Wiring Under Attack: New Study Reveals How Connexin 36 Degrades Under Stress
New research reveals how the gap junction protein connexin 36 is degraded in photoreceptor cells under excitotoxic stress, implicating autophagic, ...
Tag: proteostasis
Mitochondrial ClpX Emerges as a Key Regulator of Oocyte Quality During Ovarian Aging
A new study in Cell Death Discovery identifies the mitochondrial unfoldase ClpX as a critical guardian of oocyte quality during ...
Aging Livers Hide Their Weaknesses Until Stress Pushes Mitochondria to the Brink
A new review proposes that five interlinked biological modules, unified by mitochondrial vulnerability, explain why aging livers with the same ...
Proteostasis Collapse and Unfolded Protein Response-Mediated Neurodegeneration in Prion Disease
Prion diseases are among the rarest and most uniformly fatal neurodegenerative disorders known to medicine. Conditions such as Creutzfeldt-Jakob disease, ...
Jumping Genes and Antifreeze: New Genome Assembly Reveals How Antarctic Fish Conquered the Cold
A new phased genome assembly of the Antarctic spiny plunderfish reveals how transposon activity, antifreeze gene duplications and diversifying selection ...
Two Genes Team Up to Paint Barley Leaves in White and Green
German researchers have shown that white-striped leaves in an EMS-mutagenized barley line arise only when recessive mutations at two epistatic ...
Cell’s Insert and Undo Machines Caught Working Together in One ER Supercomplex
Cryo-EM structures reveal that the ER membrane protein complex and the Spf1 ATPase form a conserved supercomplex that juxtaposes membrane ...
Mitochondrial protein CHCHD2 emerges as a guardian of the aging brain
New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse ...
Ginseng Fights Fatigue by Switching Off Runaway Autophagy in Muscle Cells
A new mouse study shows that Panax ginseng relieves fatigue by reactivating the PI3K/AKT/mTOR pathway to suppress excessive autophagy and ...
Cell’s Cargo Trucks Caught Raising the Alarm When Protein Traffic Jams the ER
New research in C. elegans reveals that ER-to-Golgi transport proteins actively couple excess cargo to the unfolded protein response in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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