RBBP5 Emerges as a Master Epigenetic Switch Controlling the Cell’s 12-Hour Proteostasis Clock
A new PLOS Biology study identifies the COMPASS complex subunit RBBP5 as the central epigenetic regulator of the cell's 12-hour ...
Tag: proteostasis
Aging Striatum Study Reveals a Protein-RNA Switch That Drives Huntington’s Disease
A new Nature Communications study shows that age-driven upregulation of the translation regulator PPP1R15B, and declining levels of the microRNA ...
Aging May Stem From a Genome-Wide Shift That Sidelined Cellular Maintenance
A new GeroScience study finds that after sexual maturity, housekeeping genes lose transcriptional share to specialized integrative genes across species, ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Salt Stress Reveals Hidden Genes That Set the Pace of the Fruit Fly Heart
A genome-wide study in 154 fruit fly lines shows that dietary salt stress unmasks cryptic genetic variation that reshapes heart ...
Hidden Protein Networks Emerge as Central Players in Huntington’s Disease
A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...
Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
Lens Capsule Proteomics Reveals Lysosomal Breakdown Linking Cataract and Glaucoma
Proteomic analysis of human anterior lens capsules reveals that ATP6V1A-associated lysosomal dysfunction links elevated eye pressure and lens epithelial injury ...
Cellular Recycling Pathway Emerges as Central Driver of Ageing and Disease
A new review argues that chaperone-mediated autophagy, the cell's most selective protein degradation pathway, acts as a master regulator of ...
Molecular Chaperones Keep ALS Protein Droplets From Hardening Into Disease
A new review in BMC Medicine argues that ALS arises when the cellular systems that keep reversible protein condensates from ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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