Scientists Uncover Hidden Feedback Loop That Drives Colon Cancer Spread
A newly mapped SFRP2–Snai1–USP11 feedback loop stabilizes a key metastasis protein and activates PI3K/AKT/mTOR signalling, revealing fresh targets against colon ...
Tag: protein stability
Finger-Prick Device Keeps Brain Injury Biomarkers Stable Without Freezers
A new lateral flow device preserves traumatic brain injury protein biomarkers from a fingerstick blood sample for up to 21 ...
Immune checkpoint VSIR fuels gastric cancer growth by amplifying AXL signaling
New research in iScience reveals that the immune checkpoint molecule VSIR drives gastric cancer progression by transcriptionally activating and post-translationally ...
USP22 Keeps Aging Stem Cells Young by Stabilizing Key Bone-Building Protein
New research reveals that the deubiquitinase USP22 protects bone marrow stem cells from oxidative stress-induced senescence by stabilizing the transcription ...
Soda Lake Bacterium Yields Alkaline Enzymes That Boost Laundry Detergent Performance
Researchers have shown that three alkaline-stable enzymes from the soda lake bacterium Alkalitalea saponilacus significantly improve stain removal and fabric ...
Deep-Sea Protein Survives Crushing Pressure by Assembling Into Threes
Researchers at Kyushu University found that the deep-sea protein PoXeR withstands extreme hydrostatic pressure by assembling into stabilizing trimeric structures.
MutexaGPT: an intuition-to-design translator for physics-based enzyme engineering
A new framework called MutexaGPT aims to translate scientists' mechanistic intuitions into physics-grounded enzyme designs, combining large language models with ...
Protein Stability Driven by Single-Site Bias, Not Pairwise Covariance
In a groundbreaking study published in Nature Chemical Biology, researchers reveal that protein stability hinges more on the effects of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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