Tag: protein stability

A new study shows that sugar-based chemical interactions, rather than molecular crowding size, help the glycolytic enzyme PFKP stay active ...

By swapping every valine in the protein GB1 for fluorinated analogues, researchers used fluorine-19 NMR, three-bond coupling constants and gamma ...

A large-scale computational study finds that protein misfolding may underlie a substantial share of hereditary hearing loss, reclassifying tens of ...

Researchers have developed an electroporation-based NMR method that delivers labeled proteins into intact mitochondria, enabling atomic-resolution observation of alpha-synuclein membrane ...

Researchers have discovered that the deubiquitinase USP12 stabilizes the Rab GTPase-activating protein TBC1D22A, activating PI3K-AKT-mTOR signaling and driving ovarian cancer ...

Researchers replaced toxic t-butanol with a menthol-octanoic acid deep eutectic solvent to purify tea membrane-bound polyphenol oxidase 17-fold, using molecular ...

A new gradient boosting framework called VEFill accurately imputes missing deep mutational scanning scores across protein domains, outperforming existing methods ...

A bioinformatics study screened 436 variants of the IHH gene and identified 53 mutations in its receptor-binding domain that may ...

Researchers at Inha University engineered destabilized glutamine synthetase variants that dramatically increase selection stringency in CHO cells, enabling drug-free isolation ...

A new parallel deep learning framework combining CNN and Transformer branches with thermodynamic regularization improves the prediction of mutation-induced protein ...