Misfolded Proteins May Explain a Hidden Share of Inherited Deafness
A large-scale computational study finds that protein misfolding may underlie a substantial share of hereditary hearing loss, reclassifying tens of ...
Tag: protein stability
Scientists Watch Proteins at Work Inside Intact Mitochondria Using NMR
Researchers have developed an electroporation-based NMR method that delivers labeled proteins into intact mitochondria, enabling atomic-resolution observation of alpha-synuclein membrane ...
Enzyme Duo Revealed as Hidden Driver of Ovarian Cancer Growth
Researchers have discovered that the deubiquitinase USP12 stabilizes the Rab GTPase-activating protein TBC1D22A, activating PI3K-AKT-mTOR signaling and driving ovarian cancer ...
Green Solvent and Supercomputer Simulations Unlock a Stubborn Tea Enzyme
Researchers replaced toxic t-butanol with a menthol-octanoic acid deep eutectic solvent to purify tea membrane-bound polyphenol oxidase 17-fold, using molecular ...
AI Model Fills the Gaps in Protein Mutation Maps
A new gradient boosting framework called VEFill accurately imputes missing deep mutational scanning scores across protein domains, outperforming existing methods ...
Computational Screen Flags Dozens of Risky Mutations in a Key Bone Growth Gene
A bioinformatics study screened 436 variants of the IHH gene and identified 53 mutations in its receptor-binding domain that may ...
Engineered Protein Breakdown Supercharges Drug-Free Selection of High-Producing CHO Cells
Researchers at Inha University engineered destabilized glutamine synthetase variants that dramatically increase selection stringency in CHO cells, enabling drug-free isolation ...
AI Model Reads Proteins in Parallel to Predict How Mutations Reshape Stability
A new parallel deep learning framework combining CNN and Transformer branches with thermodynamic regularization improves the prediction of mutation-induced protein ...
Scientists Uncover Hidden Feedback Loop That Drives Colon Cancer Spread
A newly mapped SFRP2–Snai1–USP11 feedback loop stabilizes a key metastasis protein and activates PI3K/AKT/mTOR signalling, revealing fresh targets against colon ...
Finger-Prick Device Keeps Brain Injury Biomarkers Stable Without Freezers
A new lateral flow device preserves traumatic brain injury protein biomarkers from a fingerstick blood sample for up to 21 ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!