Watching Proteins Assemble in Real Time with a Benchtop Light-Scattering Protocol
A new open-access protocol uses continuous dynamic light scattering to track protein self-assembly minute by minute, with the full workflow ...
Tag: Protein Engineering
Engineered albumin fusion extends erythropoietin half-life and enables nasal delivery in mice
A human erythropoietin fused to an engineered albumin variant showed a 5.2-fold longer plasma half-life and successful intranasal delivery in ...
Loosening the Rim: Peripheral Flexibility Boosts a Cellulase’s Catalytic Power
Engineers boosted a GH5 endoglucanase's catalytic efficiency up to 2.73-fold by mutating solvent-exposed peripheral residues to loosen the catalytic cavity, ...
Generative AI moves crop breeding from natural selection to molecular design
A review by researchers at China Agricultural University outlines how generative AI architectures and a proposed DESIGN framework could shift ...
AI-guided enzyme search yields two new cellulases and an eightfold secretion boost in Bacillus subtilis
A new study links database-guided discovery of two uncharacterised GH5 endoglucanases with two rounds of mutagenesis and an approximately eightfold ...
Norrin complex structure guides potent engineered signaling surrogates
A structural study shows how Norrin, FZD4, TSPAN12 and LRP5 assemble, enabling engineered surrogate proteins with enhanced signaling potency.
Chemically linked phage endolysins broaden and strengthen in vitro bacterial killing
Chemically conjugating antimicrobial peptides to the phage-derived endolysin LysJEP8 strengthened in vitro killing of Acinetobacter baumannii and extended activity to ...
Engineered human AGO2 enables targeted C-to-U RNA editing in cells
Engineered human AGO2 and a C-to-U deaminase produced average messenger RNA editing 1.9-fold higher than two Cas13 comparators in HEK293T ...
Fusion Platform Recovers Previously Unproducible Bacterial Toxins
A modular toxin–immunity fusion system enables the production, purification and functional analysis of highly toxic bacterial proteins that conventional recombinant-expression ...
AI Language Model Redesigns Hemoglobin for Stronger Oxygen Binding
Using the ESM3 protein language model, researchers engineered a hemoglobin variant with enhanced stability, heme binding, and oxygen affinity, validated ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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