Single-center blood-culture analysis maps antibiotic resistance and dosing challenges in sepsis
A retrospective single-center analysis of 760 blood cultures from patients with sepsis found positive growth in 25.8% of samples and ...
Tag: Pharmacokinetics
Nebulized budesonide formulations match with and without charcoal blockade
Two randomized crossover trials found equivalent systemic exposure for test and reference nebulized budesonide in healthy Chinese adults, with and ...
Zastaprazan Disintegrating Tablet Matches Conventional Formulation Without Water
A randomized crossover trial found that zastaprazan’s orally disintegrating tablet delivers equivalent blood exposure with or without water while showing ...
What You Eat Could Decide How Well Parkinson’s Drugs Work
A new review in Frontiers in Nutrition reveals how dietary protein, meal timing, and gut bacteria competitively hijack levodopa transport ...
Rivastigmine analysis reveals the challenge of tracking a fleeting brain drug
A review of 11 validated studies shows how ultra-sensitive analysis is reshaping efforts to measure rivastigmine, a rapidly cleared brain-targeted ...
Needle-Free Blood Draw Device Keeps IV Lines Open Through Intensive Pharmacokinetic Studies
A pilot study shows a needle-free blood collection device can sustain nine venous samples per visit through a single IV ...
New Sandwich ELISA Reveals Fc Fusion Extends Feline GM-CSF Half-Life Eightfold in Cats
Researchers have developed a sandwich ELISA that quantifies both His-tagged and Fc-fused recombinant feline GM-CSF and showed that Fc fusion ...
Novel Ginseng-Derived Compound Shields the Liver From Acetaminophen Overdose by Damping HIF1α-Driven Glycolysis
A newly synthesized ginsenoside-lipoic acid hybrid called OCLA protected mice from acetaminophen-induced liver injury by directly targeting HIF1α and suppressing ...
Walnut Compound Juglone Blocks Key Drug-Metabolizing Enzyme CYP2C9 in Lab Study
In vitro experiments show juglone, a naphthoquinone from walnut green husks, potently and competitively inhibits the human drug-metabolizing enzyme CYP2C9, ...
Solusome nanovesicle tablets melt in the mouth to supercharge ebastine delivery
Researchers developed ebastine-loaded Solusome nanovesicle oral lyophilisates that disintegrate in seconds and raised the drug's oral bioavailability 3.21-fold in rats.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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