Walnut Compound Juglone Blocks Key Drug-Metabolizing Enzyme CYP2C9 in Lab Study
In vitro experiments show juglone, a naphthoquinone from walnut green husks, potently and competitively inhibits the human drug-metabolizing enzyme CYP2C9, ...
Tag: Pharmacokinetics
Solusome nanovesicle tablets melt in the mouth to supercharge ebastine delivery
Researchers developed ebastine-loaded Solusome nanovesicle oral lyophilisates that disintegrate in seconds and raised the drug's oral bioavailability 3.21-fold in rats.
Gestational age shapes vancomycin levels in neonates, study finds
A retrospective study of neonates in a Chinese intensive care unit reveals a non-linear relationship between gestational age and initial ...
Cisplatin and Oral S-1 Show Feasibility in Cancer Patients with Severe Liver Dysfunction
A seven-year prospective trial shows that oral S-1 plus cisplatin preserves overall 5-FU exposure and manageable toxicity in cancer patients ...
Fingertip blood microsampling with hematocrit-adjusted conversion shows promise for transplant drug monitoring
A validated fingertip microsampling method with individualized hematocrit-adjusted conversion can accurately monitor tacrolimus and mycophenolic acid in transplant recipients, offering ...
New Combretastatin A-4 Stilbene Derivatives Profiled for Lipophilicity by Chromatography and Computation
Researchers profiled thirty-one novel combretastatin A-4 stilbene derivatives across five chromatographic systems and computational models, finding silica-based methanol systems best ...
Ginseng Compounds Show Promise for Blood Disorders but Face Steep Translational Hurdles
A new review finds that ginseng-derived ginsenosides show context-dependent effects on healthy and malignant blood cells in laboratory models, but ...
Old drugs, new weapons: repurposing therapies against antimicrobial resistance
A comprehensive review maps how approved drugs—from anticancer agents to antidepressants—can be systematically repurposed to combat drug-resistant superbugs.
Asparaginase Levels Fall Short in Indian Children With High-Risk Leukemia, Pilot Study Finds
A pilot study from New Delhi finds consistently subtherapeutic trough asparaginase levels in Indian children with high-risk acute lymphoblastic leukemia, ...
Phage Cocktails for Farm Animals Face Tough Chemistry on the Way to the Gut
A new review examines why bacteriophage cocktails for livestock often fail outside the laboratory, highlighting gastric acid, feed pelleting, encapsulation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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