Molecular Scissors: Cysteine Peptidases Emerge as Master Switches of Antitumor Immunity
A new review in iMetaMed reveals how cysteine peptidases such as cathepsins B, S, L, and X control antigen presentation ...
Tag: PD-L1
Silencing PD-L1 Reveals a Hidden Phosphatase Axis That May Drive Gastric Cancer Survival
New research shows that silencing the PD-L1 gene in gastric cancer cells reshapes the expression of MAPK-regulating DUSP phosphatases, revealing ...
Simple Blood Test Score Predicts Which Lung Cancer Patients Benefit From Immunotherapy
A new study shows that a simple index combining hemoglobin and the albumin-to-alkaline phosphatase ratio can predict survival outcomes in ...
Blood Levels of Liver Cancer Drug Lenvatinib Predict Who Responds to Treatment
A multi-omics study of 194 liver cancer patients shows that lenvatinib blood concentrations above 26.5 ng/mL predict treatment response, while ...
Tree-Derived Compounds Packaged in Nanoparticles Strip Breast Cancer of Its Immune Shield
Researchers report that Ailanthus excelsa quassinoids delivered in chitosan nanoparticles suppress STAT3-driven PD-L1 transcription and restore T-cell antitumor activity in ...
Gut Metabolite Genes Could Predict Colorectal Cancer Survival and Immunotherapy Response
Researchers built a four-gene signature based on propionate metabolism that stratifies colorectal cancer patients by survival risk and links tumor ...
Tiny Vesicles, Big Problem: How Exosomes Drive Cancer Immunotherapy Resistance
A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...
New 3D Fluorescence Imaging Technique Maps PD-L1 in Lung Cancer to Gauge Immunotherapy Response
An exploratory study in BMC Medicine presents a three-dimensional NIR-II fluorescence molecular tomography system fused with X-ray CT that quantifies ...
Indirect Trial Comparison Suggests Retifanlimab Edges Out Avelumab in Metastatic Merkel Cell Carcinoma
A matching-adjusted indirect comparison of two landmark trials suggests retifanlimab significantly prolongs progression-free survival compared with avelumab in metastatic Merkel ...
Tumor Protein CEMIP Hijacks Immune Cells to Fuel Colorectal Cancer Drug Resistance
New research reveals that the tumor protein CEMIP drives extracellular vesicle output, reprograms macrophages by disrupting HSP90-JAK2 signaling, and enables ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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