DNA Damage Response Drives PD-L1 Shield That Lets Aging Cells Evade Immune Clearance
A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...
Tag: PD-L1
Global Training Program Achieves High Agreement in PD-L1 Scoring for Lung Cancer
The clinical significance of the tumor proportion score rests on its role as a gatekeeper for immunotherapy decisions, which is ...
How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off
New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...
New Molecular Targets Are Reshaping Personalized Treatment of Low-Grade Non-Hodgkin Lymphoma
A new Research Topic in Frontiers in Hematology highlights epigenetic targets, immunotherapy combinations, resistance mechanisms, and prognostic models driving personalized ...
Ribosomal RNA Tag and a Detox Enzyme Form a Deadly Cancer Survival Circuit
A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...
Handed-ness matters: right-handed chiral gold nanoparticles supercharge siRNA therapy against lung cancer
Intrinsically right-handed chiral gold nanoparticles with a multifaceted rhombi cuboctahedral shape deliver siRNA into lung cancer cells far more efficiently ...
Hidden Ubiquitin Switch That Lets Brain Tumors Evade Immune Attack Is Revealed
New research reveals that the ubiquitin ligase BTRC destroys the RNA-binding protein hnRNPC, whose stabilization of PSD4 mRNA boosts PD-L1 ...
Mathematical Model Points to Ways of Rewiring Tumors for Stronger Cancer Drug Delivery
A mechanistic model from Mass General Brigham and the University of Cyprus shows how normalizing the tumor microenvironment, without over-tightening ...
How a Cellular Stress Switch Helps Tumours Hide From the Immune System
A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could ...
Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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