Where does the immune pressure go? New framework explains immunotherapy resistance
A new Molecular Cancer review proposes immune-pressure redistribution as a unifying framework explaining why patients resist PD-1/PD-L1 blockade and how ...
Tag: PD-L1
Antibody-Drug Combination Falls Short in First-Line PD-L1-High Metastatic Lung Cancer Trial
The Phase 3 EVOKE-03/KEYNOTE-D46 trial found that sacituzumab govitecan plus pembrolizumab did not significantly improve progression-free or overall survival compared ...
Bispecific Antibody Meets Antibody-Drug Conjugate in Promising Small Cell Lung Cancer Trial
First clinical data from the Phase 1b/2 BNT324-01 trial show that the investigational combination of pumitamig and elfetabart drozuntecan achieved ...
ROS1 Fusion Subtype Shapes Survival in Advanced Lung Cancer, Real-World Data Show
A real-world study of 55 patients with advanced ROS1-rearranged non-small cell lung cancer shows that fusion subtype, PD-L1 expression and ...
Radium-223 Therapy Lowers PD-L1 in Prostate Cancer Bone Metastases, PET Study Shows
A prospective imaging study shows that radium-223 significantly reduces PD-L1 expression and depletes immune cells in prostate cancer bone metastases, ...
PET Imaging Reveals Whether Immunotherapy Drugs Actually Reach Their Tumour Targets
Researchers are using PD-L1-targeted PET/CT imaging to directly visualise whether the immunotherapy drug atezolizumab saturates its target in tumours, offering ...
METTL3 Emerges as a Molecular Hub Driving Tumor Immune Escape
A new review in the Journal of Translational Medicine details how the RNA methyltransferase METTL3 drives tumor immune escape through ...
PD-L1 Emerges as Key Survival Marker in Aggressive Canine Gastric Cancer
A full-thickness biopsy study of 40 dogs reveals that PD-L1 expression, rather than conventional histological features, is the strongest predictor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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