RNF152 Tags PD-L1 for Destruction and Curbs Immune Evasion in Kidney Cancer
A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...
Tag: PD-L1
Unstable Regulatory T Cells Weaken the Blood–Brain Barrier After Surgery
A study in Cell Death Discovery links perioperative destabilization of regulatory T cells to blood–brain barrier disruption through a β-catenin–tight ...
Checkpoint inhibitors improve survival in pMMR metastatic colorectal cancer meta-analysis
A meta-analysis of six randomized trials found that adding PD-1/PD-L1 inhibitors to chemotherapy was associated with longer progression-free and overall ...
Ivonescimab Extends Overall Survival Over Pembrolizumab in PD-L1-Positive Advanced Lung Cancer
A prespecified interim analysis of the phase 3 HARMONi-2 trial shows ivonescimab achieved median overall survival of 30.8 months versus ...
Checkpoint inhibitors linked to longer unadjusted progression-free survival in advanced thoracic tumors
A single-center cohort study linked checkpoint inhibitor-containing therapy with longer unadjusted progression-free survival in advanced SMARCA4-deficient thoracic tumors, but adjusted ...
Tumor Cell PD-L1 Score Predicts Longer Survival in Gastric Cancer Treated with Chemotherapy Alone
An ancillary analysis of the Japanese phase III trial JCOG1013 found that a tumor proportion score of at least 1% ...
PD-L1 and mTOR form a signaling loop that drives tumor invasion
A new review details how the immune checkpoint ligand PD-L1 doubles as a tumor-intrinsic driver of invasion through a reciprocal ...
Blood lncRNA RIME test refines who benefits from first-line ESCC immunochemotherapy
An exploratory multicenter biomarker analysis shows that pretreatment plasma lncRNA RIME, especially when combined with PD-L1, distinguishes patients with advanced ...
JAK-STAT signaling: a key mechanism of immune microenvironment remodeling in breast cancer and novel strategies for targeted therapy
A 2026 review finds that JAK-STAT signaling suppresses antitumor immunity in breast cancer, but mixed clinical trial results expose challenges ...
Ethiopian breast cancer tissue study links immune-cell infiltration to subtype and grade
An analysis of 81 Ethiopian breast cancer tissue samples associated higher immune-cell and PD-L1 measures with non-luminal subtypes and grade ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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