Hidden Prostate Cancer Patterns That Predict Deadly Disease Are Being Missed in Biopsies
A new Nature Reviews Urology review warns that intraductal and invasive cribriform prostate cancers are aggressive, genomically unstable and frequently ...
Tag: PARP inhibitors
Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Huntsman Cancer Institute Names Theresa Werner Chief of Oncology Division
Theresa Werner, MD, a gynecologic oncologist and veteran clinical trials leader, has been named chief of the Division of Oncology ...
Turning Cold Tumors Hot: Dual-Target Therapy Offers New Hope for Platinum-Resistant Ovarian Cancer
A new review outlines how combining PARP inhibitors with immune checkpoint inhibitors can convert immunologically cold ovarian tumors into hot ...
Epigenetic enzyme SMYD3 emerges as Achilles heel of gastric cancer DNA repair
New research reveals that the chromatin-modifying enzyme SMYD3 orchestrates DNA double-strand break repair in gastric cancer, and that blocking it ...
Jumping Genes May Ignite Immune Defenses in Stomach Cancers with DNA Repair Weaknesses
New research links LINE-1 retrotransposon overexpression and homologous recombination deficiency in gastric cancer to heightened immune pathway activation and potential ...
How replication stress shapes cancer evolution and opens new doors for therapy
A comprehensive new review explains how replication stress drives cancer genome evolution and why the pathways cells use to survive ...
How Cells Choose Between DNA Repair Pathways—and Why It Matters for Cancer
A new review explains how the contest between BRCA1-BARD1 and the 53BP1 axis at DNA break ends determines whether cells ...
Mutational Fingerprints Reveal the Hidden Forces Driving Prostate Cancer
A new Nature study integrates multiple classes of genomic mutations to define the distinct mutational processes that shape prostate cancer ...
LIG1 Loss Reveals Targetable Weakness Against Chemotherapy-Resistant Triple-Negative Breast Cancer
In triple-negative breast cancer (TNBC) that carries TP53 mutations, loss of one copy of the DNA ligase I gene (LIG1) ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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