CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...
Tag: PARP inhibitors
Morocco builds local HRD testing for ovarian cancer, cutting reliance on foreign labs
A Moroccan cohort study of 215 advanced ovarian cancer patients found local HRD testing feasible, with 55.1 percent of evaluable ...
BRD4 emerges as key regulator of STING expression in cancer cells
BET inhibition suppresses STING expression at its promoter and enhancer regions, weakening the immune response triggered by PARP inhibitors.
Topoisomerase I Inhibitors Pair With PARP Drugs Against Resistant Ovarian Cancer
A screen of over 1400 FDA-approved compounds identified topoisomerase I inhibitors as the most effective partners for PARP inhibitors in ...
ROS-responsive nanoparticle pairs PARP inhibitor with DOT1L blocker to fire up antitumor immunity in ovarian cancer models
A ROS-responsive nanoparticle co-delivering a PARP inhibitor prodrug and a DOT1L inhibitor amplified DNA damage, activated cGAS-STING signaling and improved ...
RNA Chaperone ALYREF Hijacks Poly-ADP-Ribose at DNA Breaks and Slows Repair in Tumor Cells
Researchers report that the RNA-processing protein ALYREF binds poly-ADP-ribose at DNA double-strand breaks, delaying repair when overexpressed and marking a ...
Replication stress marker points to ovarian cancers that may yield to ALC1 targeting
New research shows that removing the chromatin remodeler ALC1 sensitizes a broad range of ovarian cancer models to PARP inhibitors ...
Symbolic AI digital twins predict breast cancer treatment response in trial simulation
UCL and Cambridge researchers developed a symbolic AI model that built digital twins of 31 breast cancer patients and correctly ...
PARP1 Disassembles Nucleosomes to Open DNA for Repair
St. Jude researchers show the DNA repair enzyme PARP1 evicts two histones near damage sites, forming hexasomes that recruit repair ...
Blood Test Tracks Prostate Cancer’s Evolving Genome in Real Time
A comprehensive review shows circulating tumour DNA offers powerful prognostic insight across all major mCRPC treatments, but its predictive use ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!