Gut Microbes, Immune Signals and the Inflammatory Road to Parkinson’s Disease
A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...
Tag: Parkinson’s disease
DNA hydroxymethylation shifts in the striatum tracked across stages in a Parkinson’s mouse model
In a 6-OHDA mouse model of Parkinson's disease, striatal 5hmC levels and linked synaptic gene programs changed dynamically at two ...
Chronic D-serine at 200 mg/kg shows kidney toxicity signs in Parkinson’s disease rats
A rat study finds that eight weeks of daily D-serine at 200 mg/kg produces kidney inflammatory infiltrates and biological alterations, ...
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
Low Back Pain Affects Up to 88% of People with Parkinson’s Disease, Review Finds
A scoping review of twelve studies finds low back pain affects an estimated 40% to 88% of people with Parkinson's ...
Testosterone Therapy Shows Mixed Effects in Parkinson’s Disease, Review Finds
A narrative review finds that testosterone replacement therapy in Parkinson's disease shows context-dependent neuroprotective and neurotoxic effects in preclinical studies, ...
First Immune-Modulating Drug Trial Targets Neuroinflammation in Prodromal Parkinson’s Disease
A published protocol details the first randomised, placebo-controlled trial testing whether the oral drug PXS-4728A reduces PET-measured brain neuroinflammation in ...
MRI reveals nigrosome-1 neuromelanin and iron changes in Parkinson disease
Multimodal MRI shows that nigrosome-1 neuromelanin loss and iron changes, with inverted neuromelanin-iron coupling, best mark Parkinson's disease nigral degeneration.
Kurarinone curbs neuronal ferroptosis via ERα–NRF2/FTH1 pathway in Parkinson’s models
Kurarinone protected neurons from ferroptosis in cellular and mouse models of Parkinson's disease by activating an ERα-associated NRF2/FTH1 iron-sequestration pathway.
Probiotics Show Glimmers of Cognitive Benefit in Dementia Review, but the Evidence Base Is Thin
A systematic review of six randomized trials finds preliminary cognitive gains from probiotics in older adults with existing deficits, while ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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