NAT10 enzyme drives follicular atresia through ac4C modification of Tnc mRNA
A new study reports that NAT10-catalyzed ac4C modification stabilizes Tnc mRNA, inhibiting mitophagy and driving follicular atresia, with the NAT10 ...
Tag: Parkin
Magnesium Sulfate Shows Neuroprotective Effects in Mouse Model of Postoperative Cognitive Dysfunction
A new experimental study links magnesium sulfate's neuroprotective effects to AMPK/PINK1/Parkin signaling in postoperative cognitive dysfunction.
Parkin’s Metabolic Control Emerges as a Key Route to Tumor Suppression
A new open-access review summarizes evidence that the PARK2-encoded E3 ubiquitin ligase Parkin suppresses tumors by regulating mitochondrial function, redox ...
Salidroside Protects Bovine Mammary Cells From Inflammation by Activating Mitophagy
A new cell-culture study reports that salidroside protects bovine mammary epithelial cells from LPS-induced inflammatory injury by activating AMPK/mTOR signaling ...
Traditional Chinese formula blocks liver cancer cell survival by disabling mitochondrial recycling
A preclinical study reports that the herbal formula Xiaoai Jiedu recipe suppresses PINK1-mediated mitophagy and activates NLRP3 inflammasome signaling in ...
High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup
A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...
Lactate modification drives mitochondrial damage and fibrosis in diabetic hearts
A new study links lactate-driven protein lactylation to impaired mitochondrial cleanup and activated TGF-β1 signaling, offering a dual mechanism for ...
AAV gene replacement restores Parkin pathway activity in preclinical tests
An AAV carrying functional human PRKN restored mitochondrial-pathway signaling in Parkin-deficient cells and patient fibroblasts, while rodent tests showed that ...
Machine learning and cell study link shikonin to Parkin-dependent activity in hypoxic triple-negative breast cancer
A machine-learning and cell-culture study found that shikonin induced necroptosis and apoptosis in hypoxic MDA-MB-231 breast cancer cells through a ...
Brief Limb Ischaemia Cycles Shield the Kidneys by Switching On a Mitochondrial Cleanup Pathway
New research shows that remote ischaemic preconditioning protects kidneys from reperfusion injury by activating SIRT3-dependent, Parkin-mediated mitophagy in renal tubular ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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