Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Tag: NLRP3 inflammasome
Microglial NLRP3 Inhibition Restores Memory After Hemorrhagic Shock in Mice
A mouse study finds that inhibiting the NLRP3 inflammasome specifically in microglia reduces hippocampal neuroinflammation and reverses cognitive deficits after ...
Ferulic Acid Niosomes Shield Rat Testes from Chemotherapy Damage in Preclinical Study
A rat study found that ferulic acid loaded into niosomes outperformed the free compound in reducing doxorubicin-induced testicular damage across ...
CMPK2–mtDNA Axis Drives Doxorubicin Heart Damage, Study Finds
A mouse study identifies the mitochondrial enzyme CMPK2 as a key mediator of doxorubicin heart injury and reports that flavin ...
Saikosaponin A Shows Promise for Diabetic Wound Healing in Mouse Study
In a preclinical study, saikosaponin A accelerated wound closure in diabetic mice and was associated with suppressed macrophage pyroptosis and ...
Plant compounds may rewire immune metabolism in heart disease, evidence still thin
A new review maps how plant-derived compounds might modulate immune-cell metabolism in cardiovascular disease, while stressing that most evidence remains ...
Sweet Tea Flavonoid Trilobatin Eases Allergic Airway Inflammation in Mice
A new study reports that the flavonoid trilobatin reduced airway inflammation in a mouse model of asthma by suppressing NLRP3 ...
Gut Microbiota Signals Drive Pericyte Injury and Vascular Damage in Alzheimer’s Mice
A mouse study finds that depleting gut microbiota or neutralizing IL-17A protects cerebrovascular pericytes and the blood-brain barrier in an ...
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
Scientists Challenge HERV-K102 Findings in Acute Myeloid Leukemia Study
A correspondence in Blood Research raises four methodological concerns about a study linking HERV-K102 envelope deletion to pyroptosis in acute ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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