How Metabolic Reprogramming May Drive Refractory Pneumonia in Children
A new review proposes an immunometabolic framework for paediatric refractory Mycoplasma pneumoniae pneumonia, while stressing that most supporting evidence remains ...
Tag: NLRP3 inflammasome
TRPM7 Channel Drives Heart Damage After Ischemia-Reperfusion Through a Newly Traced Molecular Pathway
A new study in mice and cardiomyocytes shows that TRPM7 promotes ischemia-reperfusion heart injury through a CaMKII/DDX3X/NLRP3 pathway that drives ...
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
Mitochondria and lysosomes talk to each other, and sepsis may break that conversation
A new narrative review argues that disrupted communication between mitochondria and lysosomes may offer an organizing framework for understanding sepsis-induced ...
How Microbial Sensing May Drive Persistent Pain After Infection Clears
A new mini-review proposes that persistent microbial sensing through pattern recognition receptors may bridge acute infection and long-lasting pain.
Mitochondrial Damage May Drive Varicocele Infertility Through Oxidative Stress and Sterile Inflammation
A narrative review proposes that mitochondrial injury links varicocele-related oxidative stress and sterile inflammation, while stressing that the full pathway ...
Air Pollution May Push the Immune System from Adaptation into Dysfunction
A narrative review synthesizes evidence that airborne pollutants disrupt immune homeostasis through oxidative stress, epithelial injury and inflammatory signaling, while ...
Paeony Root Extract May Disrupt Cirrhosis’s Gut–Liver Vicious Cycle, Review Proposes
A new review proposes that total glucosides of paeony may interrupt the gut–liver axis vicious cycle driving cirrhosis, though the ...
Tibetan Herbal Formula and Ellagic Acid Ease Lung Injury in Mice by Taming Inflammasome Pyroptosis
A preclinical study reports that the Tibetan formula Zang-Si-Wei and its core component ellagic acid reduced inflammation and lung damage ...
Traditional Chinese formula blocks liver cancer cell survival by disabling mitochondrial recycling
A preclinical study reports that the herbal formula Xiaoai Jiedu recipe suppresses PINK1-mediated mitophagy and activates NLRP3 inflammasome signaling in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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