Plant Compound Bellidifolin Shields Livers From Chemotherapy Damage
A new study combining network pharmacology, molecular docking, and mouse experiments shows that the plant-derived compound bellidifolin alleviates doxorubicin-induced liver ...
Tag: NLRP3 inflammasome
RNA Methylation Enzyme METTL3 Shields the Aging Ear from Inflammatory Damage
New research shows that the RNA methyltransferase METTL3 protects against age-related hearing loss by stabilizing NFKBIA mRNA through m6A modification ...
How Microglial Metabolism and Mitochondria Drive Brain Damage After Stroke
A new review integrates mitochondrial quality control, metabolic reprogramming, and NLRP3 inflammasome activation into a single framework explaining how microglia ...
How Inflammaging Drives Heart Attacks in Older Adults—and Immunotherapy Hopes
A new review in Biogerontology links age-related chronic inflammation, cytokine dysregulation and cellular senescence to heightened heart attack risk in ...
Silencing PLSCR1 Curbs Brain Inflammation and Memory Loss in Alzheimer’s Mice by Dampening the NLRP3 Inflammasome
A new study shows that silencing the protein PLSCR1 reduces inflammatory microglial activation and improves cognition in Alzheimer's model mice ...
Cannabidiol Eases Heart Failure Damage by Rejuvenating Aging Cells and Restoring Organelle Communication
New research in mice shows that cannabidiol reduces cardiac fibrosis and diastolic dysfunction in HFpEF by clearing senescent cells, suppressing ...
Gut Bacterium Mitsuokella jalaludinii PMC73 Emerges as Gout Therapy Candidate
Researchers have isolated a human gut bacterium, Mitsuokella jalaludinii PMC73, that lowers uric acid, suppresses NLRP3 inflammasome-driven inflammation, and showed ...
Berberine Emerges as a Candidate Multi-Target Modulator of Immune Aging
A new review in Biogerontology critically evaluates berberine and its derivatives as multi-target candidates for modulating immunosenescence, the age-related decline ...
Glycolytic Enzyme Accelerates ALS by Fueling Inflammatory Neuron Death
New research shows that loss of TDP-43 in ALS drives the glycolytic enzyme ALDOA to trigger inflammatory pyroptotic death of ...
Reishi Mushroom Compounds Show Promise Against Age-Related Memory Decline in New Study
New research reports that Ganoderma lucidum polysaccharides ameliorate cognitive decline and neuroinflammation in aging by acting through a gut microbiome ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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