Immune Cell Fat Switch: Losing RORα Worsens Blinding Eye Disease in Mice
A new mouse study shows that the lipid-sensing nuclear receptor RORα restrains PPARγ-driven fat accumulation in retinal immune cells, and ...
Tag: NF-κB
Cellular Scissors: How the Deubiquitinase STAMBPL1 Shapes Health and Fuels Cancer
A new review details how the JAMM-family deubiquitinase STAMBPL1 maintains cellular homeostasis and, when overexpressed, drives tumor progression, metastasis, and ...
How Stomach Bacteria Rewire Immune Checkpoints to Fuel Gastric Cancer
A new review explains how Helicobacter pylori virulence factors drive PD-L1 expression in gastric cancer through crosstalk among the NF-κB, ...
Common Plant Compound Shields Testes From Chemotherapy Damage in Rat Study
A new rat study shows that protocatechuic acid, a natural plant-derived phenolic compound, protects testicular tissue from cisplatin-induced oxidative damage ...
Korean Red Ginseng Shields the Gut From Air Pollution Damage, Mouse Study Finds
A new mouse study shows Korean red ginseng protects the intestine from PM2.5 damage by curbing oxidative stress, preserving tight ...
Ancient Chinese Herbal Formula Shows Promise Against Disc Degeneration
A classical Chinese herbal formula, Juanbi Tang, attenuates intervertebral disc degeneration in rats by suppressing p38MAPK/NF-κB signaling, activating Atg5-dependent autophagy, ...
RNA Methylation Enzyme METTL3 Shields the Aging Ear from Inflammatory Damage
New research shows that the RNA methyltransferase METTL3 protects against age-related hearing loss by stabilizing NFKBIA mRNA through m6A modification ...
Engineered Cytisine Derivative Disrupts Redox Balance to Kill Lung Cancer Cells
Researchers engineered a thiourea-bridged cytisine derivative, YU-C-ThioU-9, that overwhelms the antioxidant defenses of lung cancer cells by disrupting Nrf2-Keap1 and ...
Natural Anthraquinone Rufigallol Shields the Spleen From Diabetes-Driven Damage in Rats
Rufigallol, a plant-derived anthraquinone, protected diabetic rats from streptozotocin-induced splenic damage by curbing oxidative stress, inflammation, and apoptosis.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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