Astrocyte Lipid Metabolism Emerges as a Central Player in ALS Progression
A new review argues that disrupted lipid handling in astrocytes may amplify motor neuron injury and disease progression in ALS.
Tag: neuroinflammation
Witnessing Defeat Is Not the Same as Suffering It: Mouse Study Shows Two Stress Models Diverge
A controlled mouse study finds that witnessed social defeat produces overlapping but distinct behavioral and hippocampal molecular effects from direct ...
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
Immunoglobulins and Efgartigimod dampen neuronal activity in rat cortical cultures
Primary rat cortical neurons express FcγRIIb and FcRn, and both immunoglobulins and the FcRn blocker Efgartigimod reduced neuronal activity in ...
Plasma exchange cuts amyloid plaques in aged Alzheimer’s model mice
A mouse study reports that monthly plasma exchange with albumin, started at an advanced stage of amyloid pathology, reduced insoluble ...
Removing Prion Protein from Human Astrocytes Alters Reactivity and Mitochondria but Not Neuronal Support
A new human cell model shows that astrocytes lacking the prion protein display increased reactivity markers and mitochondrial abnormalities, yet ...
Astrocyte-Derived Peptide Analog Shields Dopaminergic Neurons in Parkinson’s Mouse Model
A single intracerebroventricular dose of the ODN analog OP preserved tyrosine hydroxylase-positive neurons and reduced oxidative stress, inflammation, and miRNA ...
Asthma Drug Montelukast Shields Nerve Cells from Parkinson-Like Damage in Lab Study
A new cell study reports that montelukast, a common asthma medication, protected human neuroblastoma cells from rotenone-induced toxicity by modulating ...
Stem cell therapies show promise for Alzheimer’s disease, but clinical evidence remains limited
A new review finds stem cell and extracellular vesicle therapies show encouraging preclinical results for Alzheimer's disease, but published clinical ...
Varenicline’s molecular mechanisms in neuropsychiatric disorders reviewed
A new review examines how the α4β2 nicotinic receptor agonist varenicline might act on molecular pathways involved in neuropsychiatric disorders.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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