Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Tag: neuroinflammation
Astrocytes Emerge as Unexpected Players in Rare Epileptic Disorder CDKL5
Patient-derived astrocytes and human brain slice models reveal water-transport, immune and cytoskeletal abnormalities linked to CDKL5 loss.
Gut microbes linked to Alzheimer’s, Parkinson’s, Huntington’s and ALS
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.
Inflammatory stimulation reshapes microglial vesicle miRNA cargo and modestly alters recipient cells
An in vitro study found that LPS-stimulated microglia enriched miR-155 and increased miR-34a in donor cells and their extracellular vesicles, ...
Astrocytes may drive chronic traumatic encephalopathy, scoping review finds
A PRISMA-guided scoping review of 40 studies argues that astrocytes act as early, active contributors to chronic traumatic encephalopathy rather ...
Annexin A1 Emerges as a Candidate Link Between Stress Hormones and Brain Protection in Depression
A new review proposes that the glucocorticoid-regulated protein Annexin A1 may connect HPA axis dysregulation, inflammation and blood-brain barrier integrity ...
Silencing Gasdermin D Shields Hippocampal Neurons in Rat Status Epilepticus
In a lithium-pilocarpine rat model of status epilepticus, hippocampal GSDMD knockdown reduced pyroptosis and ferroptosis markers, improved neuronal survival, and ...
Microglial Activity Patterns Track Tau Buildup in Early Alzheimer’s Disease
A longitudinal PET and fMRI study links two distinct microglial activation signatures, structured by functional brain connectivity, to the spatial ...
Astrocytes May Link Gut Inflammation in IBD to Depression, Review Suggests
A new review proposes that reactive astrocytes with A1-like features may connect intestinal inflammation in IBD to comorbid depression through ...
FcRn Blockade Lowers IgG and Alters Amyloid Pathology in Alzheimer’s Model Mice
Blocking the neonatal Fc receptor with efgartigimod reduced circulating IgG and was associated with lower amyloid burden and markers of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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