Brain Protein ATIP Linked to Lower Amyloid Burden in Alzheimer’s Disease
Researchers have found that higher levels of the ATIP protein in postmortem brains of older adults with Alzheimer's disease are ...
Tag: neurodegeneration
Free Water Imaging in Parkinson’s Disease Demands Methodological Nuance, Study Argues
Researchers argue that free water imaging in Parkinson's disease produces method-dependent results that resist simple binary interpretation.
Brain-Wide Activity Ties Subcortical Decline to Spreading Tau in Early Alzheimer’s
New research in Nature Communications shows that degeneration in deep subcortical brain regions becomes progressively linked to cortical tau accumulation ...
AI Brain Age Clock Trained on Death Risk Predicts Dementia Differently in Men and Women
A new study shows that an AI brain age model trained on mortality risk from MRI scans mediates how health ...
TIMP2 Protein Levels and Gene Variants Trace Ageing and Neurodegeneration in Parkinson’s Disease
New research shows that cerebrospinal fluid TIMP2 levels rise with age and track neurodegeneration in Parkinson's disease, while TIMP2 gene ...
Right Temporal Dementia Disrupts the Brain’s Emotional Signature Networks
Researchers used fMRI pattern expression analysis to probe how right temporal variant frontotemporal dementia reshapes the brain's emotional response networks.
Polyubiquitin Repositioning Reshapes Pathological Tau Fibril Structures in Dementia
Cryo-electron microscopy reveals that repositioned polyubiquitin chains outside the ordered core can remodel tau fibril ultrastructure and shift the protofilament ...
Blood and Spinal Fluid Markers of Alzheimer’s Track Brain Plaques in a Strict Sequence
A large autopsy-validated study shows that cerebrospinal fluid and plasma Alzheimer's biomarkers become abnormal in a defined sequence as amyloid-beta ...
Huntington’s Disease Damages Brain Arterioles, but S1PR1 Stimulation Offers Reversal
A new Nature Communications study shows that Huntington's disease damages brain arterioles in a barrier-type-selective pattern coupled to reactive astrogliosis, ...
Synaptotagmins: How Calcium-Sensing Proteins Decide Whether Neurons Thrive or Die
A sweeping review of all seventeen mammalian synaptotagmin proteins reveals how failures in calcium-sensing vesicle fusion machinery can cascade from ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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