Gut Enzyme LRRK2 Rises in Crohn’s Disease but Not in Parkinson’s or REM Sleep Disorder
A French study finds colonic LRRK2 expression is strongly increased in Crohn's disease but not elevated in Parkinson's disease or ...
Tag: neurodegeneration
Time-Restricted Eating Shows Early Promise in Huntington’s Disease Pilot Trial
A 12-week pilot study found that time-restricted eating was feasible and well tolerated in 20 people with early-stage Huntington's disease, ...
Hidden Microproteins in the Aging Brain Could Reshape Alzheimer’s Research
An atlas of the aged human brain catalogs over 1,000 high-confidence microproteins, including an MKKS-encoded microprotein reduced in Alzheimer's disease ...
Fatty Acid Nitroalkenes Show Promise in Taming LRRK2 Hyperactivation in Parkinson’s Disease
New research in npj Parkinson's Disease shows that fatty acid nitroalkenes can inhibit LRRK2 kinase hyperactivation and provide neuroprotection in ...
Scientists Discover an RNA Molecule That Shields the Brain From Alzheimer’s Damage
New research shows that the long non-coding RNA Loc646329 protects neurons and improves memory in Alzheimer's model mice by sponging ...
Four Decades of Hunting the Misfolded Protein: How Prion Research Grew Into a Blueprint for Neurodegenerative Drug Design
A new review in Acta Neuropathologica chronicles four decades of Byron Caughey's pioneering work on prion disease inhibitors, from infrared ...
Hidden Microproteins in the Human Brain Map a New Frontier of Alzheimer’s Disease
A new atlas catalogues 1,067 unannotated microproteins in the human frontal cortex and reveals that a subset, including an MKKS-derived ...
New Hydrophobic Tag Molecule Degrades DAPK1 and Cuts Tau Pathology in Alzheimer’s Mice
Scientists created CJ1, a hydrophobic tagging molecule that selectively destroys the DAPK1 kinase via the proteasome, reducing tau phosphorylation, neurofibrillary ...
Scientists Clash Over Free Water Imaging as a Marker of Parkinson’s Disease Progression
A published exchange in npj Parkinson's Disease highlights the methodological debate over whether free water imaging can reliably serve as ...
New Single-Molecule Technique Reads Intact Tau Proteins at Unprecedented Scale
A new single-molecule technique called Iterative Mapping enables large-scale quantification of intact tau proteoforms in control samples, disease models, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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