Sleep Problems May Signal Widespread Functional Decline in Parkinson’s Disease
A new study in npj Parkinson's Disease links sleep disorders to decline across cognitive, motor, and daily-living domains beyond what ...
Tag: neurodegeneration
Scientists Rethink Neuronal Senescence as Brain Aging Markers Fail the Test
A new review argues that neurons can acquire senescence-like states in aging and neurodegenerative disease, but peripheral senescence markers cannot ...
Rare Disease Protein Revealed as Key Enzyme in Cellular Lipid Recycling
New research identifies the Batten disease protein CLN8 as a stereospecific acyltransferase that initiates the biosynthesis of the essential lysosomal ...
Intermittent Fasting Shows Early Promise Against Huntington’s Disease in First Human Trial
A 12-week pilot trial found that an eight-hour time-restricted eating window was feasible, well tolerated, and associated with favorable clinical ...
Silencing PLSCR1 Curbs Brain Inflammation and Memory Loss in Alzheimer’s Mice by Dampening the NLRP3 Inflammasome
A new study shows that silencing the protein PLSCR1 reduces inflammatory microglial activation and improves cognition in Alzheimer's model mice ...
Urine Chemistry Reveals Hidden Signatures of Parkinson’s Disease
Researchers used dansylated urinary metabolomics to reveal a distinctive amine and phenol chemical signature of Parkinson's disease and identify candidate ...
Base Editing Corrects Gene Mutation and Slows Motor Neuron Disease in Mice
Kyoto University researchers used adenine base editing to correct the TFG mutation behind HMSN-P, delaying disease onset and extending survival ...
ALS Protein Clumps Found Far Beyond the Brain Suggest a Whole-Body Disease
A new review finds that the pathological protein TDP-43, the hallmark of ALS, accumulates in muscle, skin, glands and other ...
Brain Mosaicism Links Development, Ageing and Neurodegeneration
A new review argues that somatic mosaicism is a pervasive feature of the human brain that links development, ageing and ...
Batten Disease Protein CLN8 Reveals a Hidden Route for Making Key Lipids
Two new studies show that the Batten disease protein CLN8 catalyzes a key step in a non-canonical phospholipid synthesis pathway ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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