New Protein Structure Alignment Tool Finds Distant Relatives Faster Than Ever
Researchers have unveiled LoL-align, a probabilistic protein structure alignment algorithm that outperforms TM-align and Dali in detecting remote homologs and ...
Tag: Nature Methods
Tangermeme toolkit turns black-box genomic AI into interpretable biology
A new open-source software package provides fast, modular tools for extracting interpretable cis-regulatory patterns from deep learning models of the ...
New AI method predicts liquid chromatography retention times without system-specific training
Researchers at the University of Jena have developed an AI method called '2-step' that predicts liquid chromatography retention times for ...
Spatial Hi-C Maps 3D Genome Folding Directly Inside Brain Tissue
A new microfluidic method called spatial Hi-C maps genome-wide 3D chromatin folding directly within intact brain tissue sections, revealing lobule-specific ...
New Method Maps Both Chromatin Access and 3D Folding in Intact Tissues
A new method called Spatial-ATAC-Hi-C simultaneously maps chromatin accessibility and three-dimensional genome organization in intact tissue sections, as demonstrated on ...
Pangenome-Powered Tool SVPG Sharpens Structural Variant Detection and Speeds Graph Updates
The new SVPG method uses pangenome graphs to detect structural variants accurately from long-read sequencing data while rapidly incorporating new ...
Deep Learning Tool Sharpens SNP Detection in Nanopore Transcriptome Sequencing
NanoTS, a new deep learning tool published in Nature Methods, enables accurate SNP detection and genotype calling from nanopore long-read ...
New Microscopy Technique Measures the Hidden Forces Cells Exert in Crowded Tissues
Researchers have developed confinement force microscopy, a tunable microconfinement platform that brings quantitative traction force measurements to cells studied under ...
New Tool Treats Genetic Ancestry as a Continuum to Sharpen Disease Risk Prediction for All Populations
A new method called SPLENDID models genetic ancestry as a continuum rather than discrete labels, significantly improving polygenic risk score ...
New Sequencing Method Maps RNA Isoforms Across Brain Cells With Single-Cell Precision
A new Nature Methods study introduces spatial isoform sequencing tools that reveal cell-type-specific RNA isoform variability across mouse brain tissue ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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