Mizzou researchers see promise in tongue exercise for ALS
A rodent study by University of Missouri researchers found that tongue exercise increased the activity of surviving motor neurons, but ...
Tag: motor neurons
Experimental ALS study identifies interferon-beta immunoproteasome pathway for TDP-43 clearance
An experimental study in ALS models found that an interferon-beta signal can increase motor-neuron immunoproteasome activity and clear aggregation-prone TDP-43 ...
Silencing SLITRK2 Rescues Damaged Nerve-Muscle Connections in FUS-ALS Motor Neurons
Researchers found that reducing SLITRK2 levels in human stem cell-derived FUS-ALS motor neurons restores axonal health and neuromuscular junction signaling, ...
Three FDA-Approved Therapies Have Transformed Spinal Muscular Atrophy, Yet Major Unmet Needs Remain
A comprehensive review details how three FDA-approved therapies have dramatically improved spinal muscular atrophy outcomes while highlighting persistent comorbidities and ...
Astrocytes Drive the Mitochondrial Traffic Jams Behind a Common Form of ALS
New research shows that astrocytes carrying the C9ORF72 mutation disrupt mitochondrial transport in motor neurons through a contact-dependent bioenergetic mechanism ...
New ALS Classification Reveals That Motor Neuron Type, Not Onset Site, Drives Survival
A population-based study of more than 2,700 ALS patients shows that a new three-axis classification decomposes prognosis, revealing that motor-neuron ...
Experimental Drug DNL343 Fails to Slow ALS Progression in Randomized Trial
A randomized clinical trial in JAMA Network Open found that 200 mg per day of DNL343, an eIF2B activator, did ...
Hidden Androgen Receptor Isoform Shows Promise Against Kennedy’s Disease
A naturally occurring short isoform of the androgen receptor, AR-A, dramatically reduces aggregation and toxicity of the mutant protein causing ...
The Brain May Be Built From Two Separate Embryonic Lineages
A new Nature Neuroscience study shows that the mammalian brain is assembled from two parallel lineage-restricted progenitors that emerge simultaneously ...
Glycolytic Enzyme Accelerates ALS by Fueling Inflammatory Neuron Death
New research shows that loss of TDP-43 in ALS drives the glycolytic enzyme ALDOA to trigger inflammatory pyroptotic death of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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