Berberine Eases Diabetic Kidney Damage by Tuning a Renal Sugar-Transport Switch
A preclinical study reports that berberine reduced kidney injury in diabetic mice and curbed glucose uptake in kidney cells through ...
Tag: molecular docking
Medicinal Plant Compounds Show Predicted Activity Against Colorectal Cancer Targets
A computational study predicts that Warburgia ugandensis phytochemicals, led by quercetin, kaempferol and bemadienolide, may bind key colorectal cancer signaling ...
Egg chemicals guide a tiny wasp’s hunt for pest moth eggs
Female Telenomus remus wasps were attracted to eggs of three moth species, and seven egg-surface compounds elicited significant behavioral responses ...
Solid lipid nanoparticles loaded with oleanolic and asiatic acid show antidiabetic potential in cell studies
Encapsulating oleanolic acid and asiatic acid in solid lipid nanoparticles preserved enzyme inhibition, lowered glucose in liver cell culture medium ...
Computational Pipeline Flags New EthR Inhibitor Candidates Against Tuberculosis
An entirely computational study reports designed 2-(3-methoxyphenoxy)-N-methylacetamide analogs that bind the tuberculosis regulator EthR more tightly than a reference inhibitor ...
Computer models point to a proline enzyme and a mystery scaffold in a salt-tolerant plant microbe
Computational modelling of two hypothetical proteins from Kosakonia cowanii F52 predicts an NAD(P)-binding Rossmann-fold oxidoreductase linked to proline metabolism and ...
Computational Design Yields Two mRNA Vaccine Candidates Against HMPV Glycoprotein
Researchers used immunoinformatics to design two multi-epitope mRNA vaccine candidates targeting the human metapneumovirus glycoprotein, reporting favorable predicted antigenicity, safety, ...
Network toxicology study maps how PFOA may disrupt male reproductive health at the molecular level
A combined network toxicology, molecular docking and in vitro study identifies ten shared genes and several pathways that may link ...
Gut Microbiome Gene Score Predicts Rheumatoid Arthritis Drug Response in New Study
A computational study built a gut microbiota–metabolite–host gene score that stratified rheumatoid arthritis patients into two molecular subtypes and predicted ...
Myricetin Targets HSP90AA1 to Curb Bladder Cancer Growth in Preclinical Models
A new multi-omics study reports that myricetin from Myrica rubra binds HSP90AA1, suppresses PI3K–Akt signaling and inhibits bladder cancer growth ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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