Two-drug cocktail reprograms heart cells into an embryonic-like state to repair damage
A simplified two-compound drug cocktail, 2SM, promoted cardiomyocyte proliferation and improved heart function after myocardial infarction in rats and mice, ...
Tag: metabolic reprogramming
Parkin’s Metabolic Control Emerges as a Key Route to Tumor Suppression
A new open-access review summarizes evidence that the PARK2-encoded E3 ubiquitin ligase Parkin suppresses tumors by regulating mitochondrial function, redox ...
Extracellular vesicles may reshape prostate cancer metabolism and its microenvironment
A new review describes how prostate cancer reverses its specialized citrate-producing metabolism and how extracellular vesicles may transfer metabolic signals ...
Cancer-associated fibroblasts rewire tumor metabolism to block immunotherapy
A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...
Gut microbes shape how well chemotherapy works in cancer patients
A review in Discover Oncology describes how the gut microbiota can modulate chemotherapy efficacy and resistance through drug sequestration, metabolic ...
TGF-β Suppresses Glycolytic Enzyme PFKM, Fueling Metabolic Shift and EMT in Lung Cancer
A new study shows that TGF-β-driven PFKM downregulation reroutes glucose toward glycogen storage and promotes invasive, mesenchymal-like behavior in lung ...
Metabolic Rewiring Emerges as a Central Driver of Liver Cancer Growth and Treatment Resistance
A new review argues that glucose, lipid, and amino acid metabolism form one interconnected network driving hepatocellular carcinoma growth, immune ...
Metabolic Enzyme BCAT1 Drives Endometriosis Cell Growth Through Histone Acetylation
A cell study finds that the enzyme BCAT1, elevated in endometriosis tissue, promotes proliferation and migration of ectopic endometrial stromal ...
Seed priming may prime plants for future stress through memory and metabolic reprogramming
A new review argues that seed priming establishes stress memory through epigenetic and metabolic reprogramming, offering a low-cost route to ...
RNA Modifications and Metabolism: Decoding Crosstalk in Liver Cancer
RNA modification networks and metabolic reprogramming establish reciprocal circuits that drive hepatocellular carcinoma progression and therapeutic resistance.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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