Pyroptosis and Metabolism: How Cancer Cells Rewire Cell Death for Therapy
A new review maps how metabolic reprogramming controls gasdermin-mediated pyroptosis in tumors and outlines a four-level evidence framework for precision ...
Tag: metabolic reprogramming
Tea Plants Under Flood Stress: Hypoxia Signals and Metabolic Trade-offs Revealed
A new review synthesizes how hypoxia signaling and metabolic reprogramming shape tea's response to waterlogging, revealing a trade-off between flood ...
Glycolysis enzymes emerge as central players in Alzheimer’s brain energy failure
A new review argues that dysregulated glycolytic and pyruvate-metabolizing enzymes in specific brain cell types form a central axis linking ...
Study reveals how VAV2 fuels glycolysis in esophageal squamous cell carcinoma
A new study reports that the signaling protein VAV2 promotes glycolytic reprogramming and tumor growth in esophageal squamous cell carcinoma ...
Ginseng Compound Rg3 Rewires Tumor Macrophages and Boosts Immunotherapy in Mice
A preclinical study reports that ginseng-derived ginsenoside Rg3 binds Glut1 on tumor-associated macrophages, reprograms their metabolism, and enhances anti-PD-1 therapy ...
MDM4 stabilizes a glycolytic enzyme to fuel growth in TP53-mutant oral cancer
A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by stabilizing the enzyme ...
Bone marrow stromal cells drive IL-6 metabolic rewiring and bortezomib resistance in multiple myeloma
Bone marrow stromal cells drive interleukin-6-mediated metabolic reprogramming and bortezomib resistance in multiple myeloma, a new open-access study reports.
Lactate Drives Immune Evasion in Pancreatic Cancer via TRMT6-SIRT5 Axis
A new study reports that lactate in the pancreatic tumor microenvironment promotes metabolic reprogramming and PD-L1 upregulation through the TRMT6-SIRT5 ...
Fasting slows colorectal cancer growth in mice by triggering IRF7-driven metabolic and immune changes
A new Cellular Oncology study reports that short-term starvation suppresses colorectal cancer cells by upregulating IRF7, which downregulates PFKFB3, induces ...
O-antigen loss helps Klebsiella pneumoniae survive meropenem stress
A study finds that O-antigen loss in Klebsiella pneumoniae enhances meropenem resistance through metabolic and redox reprogramming while creating aminoglycoside ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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