METTL14 stabilizes FDX1 RNA and restrains clear cell kidney cancer
Preclinical experiments show that METTL14 stabilizes FDX1 RNA through m6A methylation, promoting cuproptosis and suppressing clear cell renal cell carcinoma ...
Tag: m6A methylation
Circular RNA circLPAR3 blocks ferroptosis to fuel chemotherapy resistance in prostate cancer
Researchers at Nanjing Medical University report that the m6A-stabilized circular RNA circLPAR3 suppresses ferroptosis through the PCBP2/CHAC1 axis, driving docetaxel ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
Estrogen receptor fuels breast cancer growth through an RNA-tagging loop, study finds
New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the ...
Chemical Tag on mRNA Supercharges Scavenger Cells to Heal Dangerous Liver Abscesses
New research shows that the m6A-writing enzyme METTL3 speeds recovery from bacterial liver abscesses by methylating Nrf2 mRNA, which arms ...
Cellular Bridges Under Low Oxygen: How ER-Mitochondria Contacts Drive Gastric Injury
A new study reveals how hypoxia-driven ER-mitochondria contact sites and the membrane-rupturing protein NINJ1 conspire to destroy the gastric lining ...
Chemical Tags on RNA May Steer a Sheep’s Dramatic Black-to-White Coat Change
Integrated sequencing of RNA chemical modifications and gene expression reveals candidate m6A-tagged genes linked to the developmental shift from black ...
Hidden Chemical Tags on Proteins and RNA Team Up to Drive Inflammatory Bowel Disease
A new review in the Journal of Translational Medicine details how chemical tags on proteins and RNA interact to control ...
Chemical Tags on RNA Hold the Switch That Decides Whether Cells Die of Iron
A comprehensive review maps how m6A RNA methylation regulates ferroptosis across cancer, cardiovascular, neurological and metabolic diseases, revealing new therapeutic ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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