Brain Scan Fingerprints of Parkinson’s Emerge Years Before Symptoms Appear
A new resting-state fMRI study shows that Parkinson's disease-related brain network patterns can be detected in genetically at-risk people before ...
Tag: LRRK2
One Nanopore Panel Reads Out Parkinson’s Genes and Repeat Expansions Together
Researchers have built a 564-gene nanopore adaptive sampling panel that detects Parkinson's disease variants, structural rearrangements, and repeat expansions in ...
Massive Parkinson’s Genetics Study Confirms Rare Gene Variants Raise Disease Risk
New data from the 8,660-participant ROPAD cohort corroborate that ITSN1 loss-of-function variants raise Parkinson's disease risk five- to fifteen-fold, while ...
Hidden LRRK2 Overactivity Found in Parkinson’s Patients Without Known Mutations
A new study finds that about fourteen percent of Parkinson's patients without recognised pathogenic mutations show LRRK2 pathway activation as ...
Long-Read Sequencing Achieves Near-Perfect Detection of Mitochondrial DNA Variants Linked to Parkinson’s Disease
A validated PacBio HiFi long-read sequencing workflow detects low-frequency mitochondrial DNA heteroplasmy with near-perfect accuracy and reveals dynamic variant trajectories ...
Broken Cellular Recycling Plants Emerge as Common Thread in Neurodegenerative Disease
A new review in Nature Reviews Neurology argues that defective lysosomal function is a central, genetically validated driver of Parkinson ...
Gut Enzyme LRRK2 Rises in Crohn’s Disease but Not in Parkinson’s or REM Sleep Disorder
A French study finds colonic LRRK2 expression is strongly increased in Crohn's disease but not elevated in Parkinson's disease or ...
Fatty Acid Nitroalkenes Show Promise in Taming LRRK2 Hyperactivation in Parkinson’s Disease
New research in npj Parkinson's Disease shows that fatty acid nitroalkenes can inhibit LRRK2 kinase hyperactivation and provide neuroprotection in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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