Leukemia That Refuses to Choose: The Science of Mixed Phenotype Acute Leukemia
A new review in Cancer Cell International synthesizes contemporary classification, clonal biology, and precision therapy for mixed phenotype acute leukemia, ...
Tag: lineage plasticity
Single tRNA Molecule Found to Steer Prostate Cancer Between Drug Sensitivity and Resistance
Fred Hutch researchers report in Nature that a single transfer RNA, tRNA1Arg(UCU), controls whether prostate cancer cells remain androgen receptor-dependent ...
When Lung Cancer Changes Identity: Study Maps the Immune Shift Behind Drug Resistance
A paired genomic and transcriptomic study of 32 patients shows that EGFR-mutant lung adenocarcinoma transforms into an immunosuppressed yet immunologically ...
A Single tRNA Molecule Controls Whether Prostate Cancer Stays Vulnerable to Therapy
A new Nature study shows that the dosage of a single transfer RNA, tRNA1Arg(UCU), acts as a reversible molecular switch ...
How Shapeshifting Tumor Cells Outsmart Cancer Treatment
A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.
Lung Cancer Outsmarts KRAS Drugs Through Two Distinct Escape Routes
MIT researchers have found that lung adenocarcinomas can evade KRAS inhibitors either by amplifying the KRAS gene or by transforming ...
Rare Penile Metastasis From Prostate Cancer Slips Past PSA Screening
A rare case report documents prostate cancer spreading to the penis and multiple organs despite persistently low PSA levels, highlighting ...
Claudin-1 Helps Prostate Cancer Survive Chemotherapy by Easing Cellular Stress
New research reveals that the tight junction protein Claudin-1 stabilizes the ER chaperone calnexin through USP7-mediated deubiquitination, buffering lethal endoplasmic ...
How Lung Cancers Shed Their Identity to Outsmart KRAS Drugs
A new mouse study shows that lung adenocarcinomas can evade KRAS inhibitors by reprogramming their cellular identity through transcription factors ...
KIF11 Inhibition Rewires Prostate Cancer Cell Identity to Restore Sensitivity to Antiandrogen Drugs
Low-dose inhibition of the motor protein KIF11 rebuilds enhancer–promoter loops at the androgen receptor locus, restoring drug sensitivity in otherwise ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!