Cancer’s Metabolic Battleground: How Immunometabolism Became Immunotherapy’s Next Frontier
A systematic bibliometric review of more than 3,200 publications reveals that tumor immunometabolism research has surged since 2020, shifting from ...
Tag: lactate
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
Rutin Disrupts hnRNP L Condensates to Rewire Fibrotic Metabolism in Pulmonary Fibrosis
A new study in Frontiers in Pharmacology suggests that the natural flavonoid rutin binds the splicing factor hnRNP L, interferes ...
Hypoxic Microglia Attack Myelin-Forming Cells Through Lactate-Laden Vesicles and TLR4 Signaling
New research shows oxygen-starved microglia release lactate-carrying extracellular vesicles that trigger TLR4-driven inflammation and apoptosis in myelin-forming cells, offering fresh ...
How Lactate Rewrites Cell Fate: The Lactylation–Cell Death Axis That May Define Sepsis
A new review in the Journal of Advanced Research maps how sepsis-driven lactate accumulation chemically rewrites proteins through lactylation, tipping ...
Mitochondrial Metabolic Remodeling Drives Blood–Brain Barrier Dysfunction After Repetitive Mild Traumatic Brain Injury
A new review argues that recurrent mitochondrial metabolic stress, redox imbalance, and inflammatory signaling converge on the neurovascular unit to ...
Simple Blood Ratio Reveals Hidden Disease Burden in Aggressive Leukemias
Two routine laboratory measurements—serum lactate dehydrogenase and serum albumin—can be divided to yield a single number that researchers have increasingly ...
A Simple Blood Test Ratio May Reveal Hidden Kidney Scarring in IgA Nephropathy
A simple ratio derived from two routine blood tests may offer a non-invasive window into the hidden kidney damage that ...
Zinc Chemistry Breakthrough Turns Metal into a Reusable Hydrogen Battery
Researchers have used machine learning to discover that lactate ligands unlock reversible zinc oxidation, enabling a safe, circuit-free carrier that ...
Rewiring the Tumor Engine: How Metabolism Could Become Cancer’s Next Weak Spot
New research highlights microRNAs, mitochondrial ribosomal proteins and lactate signaling as promising targets against cancer's metabolic reprogramming.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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