Lactate tags EZH2 protein to worsen sepsis lung injury in mice
A new study in mice and human endothelial cells shows that lactate-driven EZH2 lactylation at lysines 30 and 406 promotes ...
Tag: lactate
Cancer-associated fibroblasts rewire tumor metabolism to block immunotherapy
A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
ECHS1 Linked to Hypoxia-Driven PGK1 Crotonylation in Prostate Cancer Models
A new study links the metabolic enzyme ECHS1 to hypoxia-responsive PGK1 crotonylation and malignant phenotypes in prostate cancer cell and ...
Capillary Refill Time Targets Trim Early Fluids in Septic Shock Trial
A randomized trial found that capillary refill time-guided resuscitation was associated with about 250 mL less intravenous fluid in the ...
Lactate modification drives mitochondrial damage and fibrosis in diabetic hearts
A new study links lactate-driven protein lactylation to impaired mitochondrial cleanup and activated TGF-β1 signaling, offering a dual mechanism for ...
Research report: Mechanistic insights into lactate-driven pathogenesis in diabetic kidney disease
A narrative review assembles preclinical evidence that lactate signaling and lysine lactylation may connect metabolic reprogramming, inflammation and fibrosis in ...
Blood Flow Restriction Exercise Acutely Raises BDNF in Healthy Older Men
A randomized trial in GeroScience reports that a single bout of blood flow restriction training acutely increased circulating BDNF and ...
Moderate exercise protects against osteoarthritis in mice through gut microbes
In a mouse osteoarthritis model, moderate treadmill exercise altered the gut microbiota, lowered circulating lactate and reduced cartilage damage through ...
A Single Inflammatory Signal at 72 Hours Predicts Who Survives Cardiogenic Shock
Researchers in Marburg found that interleukin-6 levels measured 72 hours after implantation of a microaxial flow pump independently predict 30-day ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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