Lactate Drives Immune Evasion in Pancreatic Cancer via TRMT6-SIRT5 Axis
A new study reports that lactate in the pancreatic tumor microenvironment promotes metabolic reprogramming and PD-L1 upregulation through the TRMT6-SIRT5 ...
Tag: lactate
Cerebrospinal Fluid Analysis: From Lumbar Puncture Technique to Clinical Biomarker Interpretation
A new narrative review maps how cerebrospinal fluid physiology, lumbar puncture technique, and phase-based biomarker interpretation underpin neurological diagnosis.
Sepsis Resuscitation Shifts Focus to Tissue Perfusion Over Fluid Rules
A new commentary argues that early sepsis care should target tissue perfusion directly, since large trials show neither early vasopressors ...
In vivo isotope tracing maps fat-making flux in KRAS lung tumors and host tissues
In vivo isotope tracing in KRAS-driven lung cancer mouse models shows that tumor fat synthesis draws mainly on lactate and ...
Glycolysis Metabolites Linked to Short-Term Mortality After Heart Attack
A study of 724 STEMI patients found that elevated glucose, lactate, pyruvate and citrate were each significantly associated with death ...
Blood gas readings at the emergency door flag who is most likely to die
A retrospective German cohort study finds that anemia, acidosis and low bicarbonate on initial point-of-care blood gas analysis were independently ...
Exercise-linked lactate may remodel the post-stroke brain through tubulin modification
A new review argues that lactate released during aerobic exercise could modify the neuronal protein α-tubulin and support neural remodeling ...
Lactate tags EZH2 protein to worsen sepsis lung injury in mice
A new study in mice and human endothelial cells shows that lactate-driven EZH2 lactylation at lysines 30 and 406 promotes ...
Cancer-associated fibroblasts rewire tumor metabolism to block immunotherapy
A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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