RNA-binding protein MSI1 keeps stem cells pluripotent by steering iron to DNA demethylation machinery
A new study shows that the RNA-binding protein MSI1 stabilizes the ferritin-like transcript Fthl17c, preserving the ferrous iron supply that ...
Tag: Iron homeostasis
Newly identified piRNA linked to congenital heart disease in foetal rats
Researchers identified the piRNA CHDPIR, upregulated in maternal plasma extracellular vesicles and foetal heart tissue in congenital heart disease, and ...
Bacteria’s Antioxidant Defenses Mapped in Systematic Review of 27 Studies
A systematic review of 27 studies maps how Gram-positive and Gram-negative bacteria use enzymes, thiols, metal homeostasis, and biofilm matrices ...
Perifosine disrupts iron and copper balance, slowing growth in fruit flies
A Drosophila study reports that developmental exposure to perifosine causes growth retardation by disrupting iron and copper homeostasis, with quercetin ...
Iron Overload, Ferroptosis and the Liver: Mapping a Deadly Network
A new review maps how disrupted iron homeostasis and ferroptosis drive liver disease, from hereditary hemochromatosis to hepatocellular carcinoma, and ...
Iron Levels Shift in Fatty Liver Disease, but Fibrosis Link Stays Unclear
A prospective case-control study of 60 Egyptians found that patients with metabolic dysfunction-associated fatty liver disease had higher ferritin and ...
Kurarinone curbs neuronal ferroptosis via ERα–NRF2/FTH1 pathway in Parkinson’s models
Kurarinone protected neurons from ferroptosis in cellular and mouse models of Parkinson's disease by activating an ERα-associated NRF2/FTH1 iron-sequestration pathway.
ACTN4 protein target disrupts iron recycling and triggers ferroptosis in leukemia cells
A new open-access study shows that pseudolaric acid B binds ACTN4, disrupting TfR1 recycling and driving iron-dependent ferroptosis in acute ...
Small comparative study links elevated hepcidin to untreated Graves’ disease in children
A comparative study of 42 children found higher hepcidin, ferritin, inflammation and antibody levels and lower serum iron in untreated ...
Resveratrol pretreatment accompanies fewer DBDPE-associated changes in female mice
A 28-day female-mouse study found that resveratrol pretreatment was associated with lower values for several DBDPE-associated organ-index, redox and iron-related ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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