Inherited IL-10 Gene Pattern Flags Septic Shock Risk in ICU Patients
A prospective study of 492 sepsis patients links inherited IL-10 haplotype combinations to dramatically altered odds of progressing to septic ...
Tag: interleukin-10
Engineered Nanobody Drug Tames Inflammation by Rewiring IL-10 Receptor Geometry
Scientists have engineered a tetravalent nanobody agonist that harnesses differential TYK2 dependence and receptor abundance to deliver IL-10's anti-inflammatory power ...
Regulatory Immune Cells Rise With Lung Cancer Severity, Blood Study Finds
A prospective case-control study reports that circulating regulatory B cells, regulatory T cells, and a broad serum cytokine panel are ...
Common Antibiotic Calms Children’s Wheezing by Rewriting Inflammatory Memory in Lung Immune Cells
A new study shows azithromycin eases post-inflammatory wheezing in children by inhibiting SETD1B-driven H3K4me3 methylation and rebalancing macrophage polarization in ...
Gut Microbes Prime Regulatory B Cells That Shape Cancer Immunotherapy Outcomes
A new review explains how gut microbes program immunosuppressive regulatory B cells through cytokine and metabolite signals, with major implications ...
Diabetes Drug Metformin Shows Promise Against Deadly Pancreatitis in Obesity, Gut Microbe Study Finds
New research in the Journal of Translational Medicine shows that metformin reduces pancreatic and lung injury in obese mice with ...
Scientists Create Proteins That Switch On Only Where Inflammation Burns
Researchers have engineered proteins that remain inactive until nitric oxide in inflamed tissue chemically restores their function, enabling targeted therapeutics, ...
Gut-Derived Toxin and Cytokine Patterns Track Depression Severity, Study Finds
A new study finds that gut-derived lipopolysaccharide marks mild-to-moderate depression while TNF-alpha tracks severe depression, suggesting distinct inflammatory subtypes of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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