Gene Networks Point to Interferon Decline as Driver of Severe Dengue in India
A whole-blood transcriptomic study of 112 dengue patients in New Delhi links depressed interferon responses and altered glycosylation pathways to ...
Tag: innate immunity
Neutrophil Traps and Inflammatory Macrophages Team Up in Failing Hearts
New human heart tissue analysis reveals that excessive neutrophil NET formation in heart failure is strongly linked to a shift ...
Cell Study Reveals How TRIM28 Fires Up Inflammatory Macrophages to Drive Keratinocyte Overgrowth
New laboratory research shows that the protein TRIM28 drives macrophages toward a pro-inflammatory state through the NLRP3/SGT1 axis and SUMOylation, ...
Aging Blunts a Protective Gut Lipid Defense That Keeps COVID-19 Mild
New research in aged hamsters shows that COVID-19 severity may hinge on an age-dependent failure of the gut to produce ...
Diesel Soot Paralyzes the Lung’s Resident Scavenger Cells, New Study Finds
New research shows diesel particulate matter disables the lung's resident alveolar macrophages by disrupting actin-driven movement and bacterial engulfment, causing ...
STING and p53 Rise in HPV-Linked Skin Cancers, Landmark Study Finds
Researchers in São Paulo report that skin cancers arising in patients with epidermodysplasia verruciformis show markedly higher STING and p53 ...
Scientists Reverse Radiotherapy Resistance in Lung Cancer by Rewiring the Immune Microenvironment
New research shows that lung tumors become radioresistant through ATR signaling activation and immune suppression, but innate immune agonists and ...
Lung Bacteria Found to Worsen Influenza Through a Metabolic Trap in Immune Cells
Researchers found that Bacillus cereus colonization of the lungs exacerbates influenza A virus infection by releasing xanthosine, which suppresses the ...
Macrophages move captured proteins onto their own surface during live-cell uptake
New research shows that macrophages can transfer functionally active proteins from engulfed live cells onto their own surface rather than ...
Mapping STING Mutations to Unlock Immunity and New Therapies
A comprehensive atlas of STING mutations consolidates genetic, structural, and clinical data to clarify how variants drive autoinflammation, immunodeficiency, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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