Infection Rewires a Histone Tag to Boost Macrophage Defenses Through an ID3-ZBP1 Circuit
A new study shows that Salmonella infection removes an acetyl tag from histone H2B, silencing the ID3 gene and weakening ...
Tag: innate immunity
Cancer Must Silence Its Own Viral Alarm to Become Malignant, Review Argues
A Nature Reviews Cancer review argues that escaping the antiviral viral mimicry response triggered by derepressed transposable elements is a ...
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
Natural Killer Cell Education Leaves Lasting Imprints on the Persistent HIV Reservoir
New research in Nature Immunology shows that KIR2DL1-educated natural killer cells leave durable imprints that shape which HIV-1 reservoir cells ...
AI-Designed Gasdermins Programmed to Destroy Virus-Infected Cells
A Cell Research article examines how artificial intelligence-guided engineering of gasdermin pore-forming proteins could be harnessed to selectively eliminate virus-infected ...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
Cryo-EM structures of human NLRP6 in ATP-bound and unbound conformations reveal how ATP serves as an endogenous inhibitor of inflammasome ...
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory ...
Blood Proteins Reveal Distinct Immune Signatures of Alzheimer’s Impairment and Shrinkage of the Hippocampus
A study of 506 ADNI participants finds that plasma complement–acute-phase protein signatures track cognitive and functional impairment while endothelial-associated signatures ...
How Microbial Adhesion Switches On Piezo1 to Launch Innate Immunity
A new Nature Immunology study shows that microbial adhesion to myeloid cells activates the mechanosensitive ion channel Piezo1, triggering a ...
Targeting Host RNA-Binding Proteins Could Yield Broad-Spectrum Antivirals
A new review in npj Viruses argues that host RNA-binding proteins, which many unrelated viruses hijack during replication, could serve ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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