Fish-Specific Ubiquitin Ligase NHRE3 Helps Virus Evade Antiviral Defenses by Degrading ISG15
Researchers identified a fish-specific E3 ubiquitin ligase, NHRE3, that suppresses antiviral immunity in grass carp and rare minnows by tagging ...
Tag: innate immunity
Immune Gene Variants Hint at Why Some Children Develop Severe Hand, Foot, and Mouth Disease
A candidate-gene study of Chinese Han children finds nominal links between complement-related gene variants and severe Coxsackievirus A6 hand, foot, ...
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Gut Fat Molecules Steer a Worm’s Immune Defenses and Its Urge to Flee Pathogens
A new study in PLOS Biology shows that the nuclear hormone receptor NHR-68 links intestinal linoleic acid metabolism to both ...
Ancient IL-1 Cytokines Found Across the Animal Kingdom, Rewriting Inflammation’s Origins
Protein structure prediction has revealed an ancient family of IL-1 cytokines spanning cnidarians to vertebrates, indicating that the inflammatory IL-1/IL-1R ...
Methotrexate Blunts Neutrophil Migration and Boosts LOX-1 Expression, Study Finds
New research shows methotrexate selectively impairs neutrophil chemotaxis while increasing LOX-1 expression, leaving other key neutrophil functions untouched.
Genetic Variant in Surfactant Protein D May Shield Carriers From Severe COVID-19
A large Czech case-control study finds that carriers of the T allele of the SFTPD rs721917 variant may be modestly ...
Zebrafish Help Scientists Solve a 30-Year Mystery of an Inflammation Signal That Both Alarms and Shields
MSK scientists identified the long-unknown enzyme behind the inflammatory signal 5-oxoETE and discovered that the pathway also protects healthy cells ...
Cutting Calories Quietly Disarms the Inflammasome Driving Obesity’s Chronic Inflammation
A six-month hypocaloric diet that cut body weight by about 10 percent significantly suppressed NLRP3 inflammasome priming, oxidative stress, and ...
Chemical Tag on mRNA Emerges as Master Switch Behind Tumor Immune Evasion
A new review in the Journal of Translational Medicine details how the m6A RNA modification acts as a bidirectional switch ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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