Timing Is Everything: Switching an Immune Switch On and Off Repairs Spinal Cord Injury in Mice
A new mouse study shows that activating the cGAS-STING immune pathway early after spinal cord injury and inhibiting it later ...
Tag: innate immunity
APOE ε4’s Health Effects Flip Depending on Where and How People Live
A study of Kenya's Turkana and Malaysia's Orang Asli shows that the APOE ε4 allele's effects on cholesterol, immunity, and ...
Rare Sugar D-Allose Rewires a Mitochondrial Stress Circuit to Slow Disc Degeneration
A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...
Kawasaki disease emerges as a model for decoding childhood inflammatory disorders
A new editorial in Pediatric Research argues that Kawasaki disease should serve as a prototypic model for understanding the spectrum ...
Vaccine adjuvant K3-SPG offers mice temporary shield against respiratory viruses
A University of Tokyo study shows the adjuvant K3-SPG can train innate immunity in mice to provide temporary protection against ...
Ancient Chinese Herb Powder Rides to the Rescue of Weaning-Stressed Goat Kids
A finely ground powder of the traditional Chinese herb Astragalus membranaceus significantly boosted the complement regulator C4bp and antibody IgM ...
How a Pathogen Hijacks Nerve Signals to Break Down a Worm’s Skin
Researchers discovered that the bacterium Pseudomonas aeruginosa exploits neuronal signaling in C. elegans to impair lysosomal function and disrupt collagen ...
BRCA Carriers Show Distinct Protein Signatures in Healthy Breast Tissue, Study Finds
A Mayo Clinic-led proteomic study of nearly 5,000 proteins in nonmalignant breast tissue reveals that cancer-free BRCA1/2 mutation carriers show ...
How Pathogens Hijack Mitophagy and What It Means for Treating Infection
A new review details how bacteria and viruses hijack or block the mitochondrial quality-control pathway of mitophagy to survive, evade ...
Dry Eye Disease Rewired: How Inflammation Drives a Self-Amplifying Loop in the Eye
A new review argues that dry eye disease is sustained by a self-amplifying inflammatory circuit linking the corneal epithelium, immune ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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