Macrophages move captured proteins onto their own surface during live-cell uptake
New research shows that macrophages can transfer functionally active proteins from engulfed live cells onto their own surface rather than ...
Tag: innate immunity
Mapping STING Mutations to Unlock Immunity and New Therapies
A comprehensive atlas of STING mutations consolidates genetic, structural, and clinical data to clarify how variants drive autoinflammation, immunodeficiency, and ...
Targeted SAP Domain Mutations Weaken Foot-and-Mouth Disease Virus Virulence
Engineered mutations in the SAP domain of the foot-and-mouth disease virus leader proteinase attenuate the virus while preserving its replication ...
Ageing Bone Cells Lose a Key Epigenetic Brake, Driving Osteoporosis
New research reveals that loss of the epigenetic regulator Prmt6 triggers a Sting–Ifitm3 immune cascade that senesces osteoblasts and accelerates ...
Infection Rewires a Histone Tag to Boost Macrophage Defenses Through an ID3-ZBP1 Circuit
A new study shows that Salmonella infection removes an acetyl tag from histone H2B, silencing the ID3 gene and weakening ...
Cancer Must Silence Its Own Viral Alarm to Become Malignant, Review Argues
A Nature Reviews Cancer review argues that escaping the antiviral viral mimicry response triggered by derepressed transposable elements is a ...
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
Natural Killer Cell Education Leaves Lasting Imprints on the Persistent HIV Reservoir
New research in Nature Immunology shows that KIR2DL1-educated natural killer cells leave durable imprints that shape which HIV-1 reservoir cells ...
AI-Designed Gasdermins Programmed to Destroy Virus-Infected Cells
A Cell Research article examines how artificial intelligence-guided engineering of gasdermin pore-forming proteins could be harnessed to selectively eliminate virus-infected ...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
Cryo-EM structures of human NLRP6 in ATP-bound and unbound conformations reveal how ATP serves as an endogenous inhibitor of inflammasome ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!