Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Tag: induced pluripotent stem cells
Astrocytes Emerge as Unexpected Players in Rare Epileptic Disorder CDKL5
Patient-derived astrocytes and human brain slice models reveal water-transport, immune and cytoskeletal abnormalities linked to CDKL5 loss.
Stem Cell-Derived T Cells Offer New Human Model for Genotoxicity Testing
Researchers developed an in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes, which showed normal karyotype, intact ...
Prime and Base Editing Correct ALS-Causing SOD1 Mutations in Human Stem Cells
Researchers corrected two SOD1 mutations linked to familial ALS in human induced pluripotent stem cells, achieving roughly 10% correction with ...
Patient-Derived Heart Cells Reveal Susceptibility to Osimertinib-Induced Cardiac Dysfunction
Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking ...
3D Printed Molds Enable Rapid Thermoformed Polycarbonate Cell Culture Tools
A DLP 3D printing and polycarbonate thermoforming workflow produces custom, transparent, autoclavable cell-culture accessories validated with human induced pluripotent stem ...
Removing Prion Protein from Human Astrocytes Alters Reactivity and Mitochondria but Not Neuronal Support
A new human cell model shows that astrocytes lacking the prion protein display increased reactivity markers and mitochondrial abnormalities, yet ...
Chromatin Study Links Inflammation to Endothelial Remodeling in Capillary Malformations
An integrative ATAC-seq and RNA-seq study of induced endothelial cells from capillary malformation patients identifies inflammation-associated chromatin remodeling and distal ...
Stem cell therapies show promise for Alzheimer’s disease, but clinical evidence remains limited
A new review finds stem cell and extracellular vesicle therapies show encouraging preclinical results for Alzheimer's disease, but published clinical ...
Adult ADHD-linked PARK2 variants subtly reshape lab-grown blood-brain barrier cells
Lab-grown blood-brain barrier cells from adults with ADHD carrying PARK2 copy number variations show small genotype-linked changes, while culture duration ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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