Immune Checkpoint Drugs May Trigger Nerve Damage in Patients Primed for Neuroinflammation
A large analysis of melanoma patients treated with immune checkpoint inhibitors finds that 12 percent develop significant neurotoxicity, often within ...
Tag: Immunotherapy
Engineered Immune Cells Edge Closer to Becoming a Real Weapon Against Breast Cancer
A new review maps the engineering strategies, from dual-target receptors to tumor microenvironment remodeling, that could finally bring CAR-T cell ...
Chemoimmunotherapy Before Surgery Lets Some Head and Neck Cancer Patients Skip High-Dose Radiation
A phase II trial found that preoperative chemo-immunotherapy with sintilimab achieved major pathological responses in 59.1 percent of locally advanced ...
AI-Designed Protein Drug Recruits Immune Cells to Fight Gastric Cancer—With a Helping Hand from Dendritic Cells
A team at Nanjing Medical University used RFdiffusion to design a CLDN18.2-targeting T-cell engager for gastric cancer and showed that ...
Simple Blood Test Score Predicts Which Lung Cancer Patients Benefit From Immunotherapy
A new study shows that a simple index combining hemoglobin and the albumin-to-alkaline phosphatase ratio can predict survival outcomes in ...
Gut microbes and T cells drive chronic liver disease through a two-way immune dialogue
A new review maps how gut microbes and their metabolites bidirectionally shape T cell immunity to drive autoimmune, alcohol-associated, metabolic ...
Cancer’s Sphingolipid Code: How One Lipid Family Decides Cell Fate Across Tumors
A new review in Molecular Biology Reports maps how the ceramide–S1P balance and ganglioside signaling form a cancer-type-specific lipid code ...
PET tracer lights up ferroptosis to track liver cancer immunotherapy in real time
Researchers combined anti-PD-L1 immunotherapy with the PARP inhibitor Olaparib to trigger ferroptosis in liver cancer and used the SLC7A11-targeted PET ...
How aging and sex reshape the immune system’s fight against cancer
A new Nature Aging study from Mass General Brigham shows that male and female immune systems age differently, with earlier ...
When Lung Cancer Changes Identity: Study Maps the Immune Shift Behind Drug Resistance
A paired genomic and transcriptomic study of 32 patients shows that EGFR-mutant lung adenocarcinoma transforms into an immunosuppressed yet immunologically ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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