Blood-based scores and immune biomarkers reshape outcome prediction in blood cancers
A 2026 narrative review synthesizes evidence that inflammatory blood ratios, endothelial scores, and CAR-T-specific tools can stratify outcomes in hematologic ...
Tag: Immunotherapy
New mouse model of metastatic prostate cancer opens door to combination immunotherapy studies
Researchers developed PL051, a syngeneic mouse prostate cancer cell line that is androgen-dependent, metastatic and immunocompetent, enabling tests of combined ...
DUSP4 protein keeps cancer-killing T cells active against colorectal tumours
NUS Medicine researchers found that the protein DUSP4 helps CD8+ T cells retain their cancer-killing function and that boosting its ...
NRF2 Regulates Ferroptosis Vulnerability and Immune Responses in Endometrial Cancer Models
Researchers found that NRF2 regulates inflammatory adaptation, ferroptotic vulnerability, and interferon-gamma immune signaling across endometrial carcinoma models and clinical datasets.
Review Explores Metabolic Reprogramming of Regulatory T Cells in Colorectal Cancer
A review in the Journal of Translational Medicine examines how metabolic reprogramming enables regulatory T cells to drive immunosuppression in ...
Lactylation Links Glycolysis to Cancer Cell Division in Preclinical Study
Researchers found that glycolysis-derived lactate triggers PGK1 lactylation to activate Aurora B, driving cancer cell division and tumour growth in ...
Pulsed Low-Dose-Rate Radiotherapy Reshapes Immune Cells Around Tumors
A study evaluates pulsed low-dose-rate radiotherapy and finds the spatial distance between SPP1-positive TAMs and GZMK-positive CD8-positive T cells is ...
SMARCAL1 condensates drive radioresistance and immunosuppression in tumours
A new study shows that SMARCAL1 forms nuclear condensates that reprogram chromatin and methionine metabolism, weakening radiotherapy and immunotherapy responses.
TAM receptors and STAT–SOCS signaling shape the immune landscape of thymic epithelial tumors
A new integrative analysis links TAM receptor and STAT–SOCS signaling to immune infiltration patterns in thymic epithelial tumors.
DNA repair gene mutations flag better immunotherapy responses in FH-deficient kidney cancer
A multicenter study found that FH-deficient kidney cancer patients with DNA damage repair gene mutations showed significantly higher response rates ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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