Advances in Organoid Coculture Platforms for Cancer Research and Immunotherapy
A systematic review evaluates how organoid coculture models reconstitute tumor microenvironments to improve preclinical drug screening and immunotherapy evaluation.
Tag: Immunotherapy
Computational predictions map private neoantigens and cell-surface targets in malignant peripheral nerve sheath tumours
A computational analysis of public sequencing data predicts a private neoantigen repertoire and copy number driven cell-surface targets in malignant ...
Skin patch aims to reprogram a patient’s own cells into living medicine
A Virginia Tech researcher has received a five-year NIH award to develop a microneedle patch that could attract, reprogram and ...
Tumor heterogeneity shapes responses to STING and LTβR-mediated TLS induction
A new study shows that tumor heterogeneity significantly impacts the success of STING and LTβR-mediated tertiary lymphoid structure induction in ...
Phase 2 Trial of Neoadjuvant Durvalumab and Tremelimumab with Chemotherapy Does Not Meet Primary Endpoint in Advanced High-Grade Serous Ovarian Cancer
A phase 2 trial found that adding immunotherapy to chemotherapy did not improve the primary efficacy endpoint in advanced ovarian ...
HCC Drug Rankings Confounded by Trial Populations
A Bayesian network meta-analysis reveals that class-level rankings for first-line HCC immunotherapy are confounded by trial population characteristics, rendering drug ...
Study Links TACE Plus Camrelizumab to Better HCC Outcomes
A retrospective study in BMC Cancer found that adding camrelizumab to TACE and apatinib improved response and survival in elderly ...
Two Decades of Cancer siRNA Research Reveal Shifts Toward Nanocarrier Delivery
A bibliometric analysis of more than 27,000 publications tracks the growth of cancer siRNA therapies, shifting delivery technologies, and persistent ...
Sublingual Immunotherapy Linked to Lower Respiratory Disease Worsening Over Three Years
A target-trial emulation involving 2,713 patients with allergic respiratory disease found that initiating sublingual immunotherapy was associated with reduced disease ...
Plasma extracellular vesicle immunoassay maps immune checkpoint proteins in breast cancer
Researchers developed a multiplexed immunoassay that measures immune checkpoint proteins on the surface of plasma extracellular vesicles and found generally ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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