c-MET Signaling Reshapes the Lung Cancer Immune Landscape in Space and Metabolism
A new review in the Journal of Translational Medicine argues that c-MET signaling shapes spatially confined, metabolically driven immunosuppressive niches ...
Tag: immunometabolism
Fat Hormones Surge After Severe Trauma and May Signal Organ Failure Risk
A German study tracking fat-derived hormones in severely injured patients found that a surge in resistin and a drop in ...
Engineered CAR-T Cells That Make Their Own IL-2 Show Stronger Staying Power Against Pancreatic Cancer
A preclinical study shows that CAR-T cells engineered to secrete an Fc-fused IL-2(C125S) variant persist longer, retain mitochondrial fitness, and ...
Hidden immune cell states may reveal which sepsis patients will survive
Single-cell sequencing has revealed five distinct developmental states of monocytic myeloid-derived suppressor cells in sepsis, and a combined VSIG4 and ...
CBD Rewires the Liver Transcriptome and Calms Inflammatory Cytokines in Mice
A new mouse study shows cannabidiol suppresses pro-inflammatory cytokines while driving profound, dose- and time-dependent gene expression changes in the ...
Rewiring the Engine: How Metabolism Could Unlock CAR-T Cells for Solid Tumors
A new review argues that engineering the metabolism of CAR-T cells, alongside neutralizing the hostile chemistry of tumors, is the ...
Blocking a Single Kinase May Steer Immune Cells Toward Safer Atherosclerotic Plaques
New research shows that removing protein kinase C delta reprograms macrophage metabolism to suppress inflammatory pyroptotic cell death and stabilize ...
Immune Enzymes from Neutrophils Block Thermogenic Rewiring of Visceral Fat
A new Nature Metabolism study shows that neutrophil-derived serine proteases actively block the thermogenic beiging of visceral fat, explaining why ...
Blood Proteins May Reveal Who Benefits Most From Lung Cancer Immunotherapy
The prospective SARC-LUNG study links circulating immunometabolic biomarkers such as sRAGE and FGF21 with survival and immune microenvironment profiles in ...
Macrophage Itaconate Suppresses Heat Production in Fat Tissue
A newly published study has unveiled a surprising immunometabolic interaction that dampens heat production in fat tissue. Researchers led by ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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