Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure
A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...
Tag: immunometabolism
Metabolism Holds the Key to Stronger CAR T Cell Therapies, Review Argues
A Nature Reviews Cancer review argues that metabolism, from CAR design and manufacturing conditions to the patient's diet, is a ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
A Common Amino Acid Throws a Molecular Wrench Into the Body’s Inflammation Machine
New research shows the dietary amino acid l-arginine directly binds the NLRP3 inflammasome and blocks its assembly, easing inflammatory and ...
The Amino Acid Arginine Emerges as a Brake on the NLRP3 Inflammasome
A Nature Metabolism commentary highlights new evidence that the amino acid l-arginine can inhibit activation of the NLRP3 inflammasome, raising ...
Brain-Style NMDA Receptors Rewire Immune Cells Inside Tumors, Review Finds
A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...
c-MET Signaling Reshapes the Lung Cancer Immune Landscape in Space and Metabolism
A new review in the Journal of Translational Medicine argues that c-MET signaling shapes spatially confined, metabolically driven immunosuppressive niches ...
Fat Hormones Surge After Severe Trauma and May Signal Organ Failure Risk
A German study tracking fat-derived hormones in severely injured patients found that a surge in resistin and a drop in ...
Engineered CAR-T Cells That Make Their Own IL-2 Show Stronger Staying Power Against Pancreatic Cancer
A preclinical study shows that CAR-T cells engineered to secrete an Fc-fused IL-2(C125S) variant persist longer, retain mitochondrial fitness, and ...
Hidden immune cell states may reveal which sepsis patients will survive
Single-cell sequencing has revealed five distinct developmental states of monocytic myeloid-derived suppressor cells in sepsis, and a combined VSIG4 and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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