Lupus quietly doubles down on heart disease, and standard risk scores miss it
A new Frontiers in Lupus Research Topic shows that cardiovascular risk in systemic lupus erythematosus arises from a complex interplay ...
Tag: immunometabolism
The Aging Gut’s Chemical Factory: How Microbial Metabolites Shape Organ Health in Old Age
A comprehensive narrative review maps how age-related changes in gut microbial metabolism — from short-chain fatty acids to bile acids ...
Charged-Up Exosomes From Energy-Boosted Cells Heal Stubborn Diabetic Wounds
Researchers show that AICAR-activated endothelial cells release GAS6-carrying exosomes that reprogram macrophages and rebuild blood vessels, dramatically accelerating diabetic wound ...
Cellular Powerhouse Clues: TCA Cycle Disruptions Linked to Fatigue and Low Mood in Obesity
A translational study links disrupted TCA cycle metabolites to fatigue and reduced motivation in obesity, with brain-region-specific findings in mice.
Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure
A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...
Metabolism Holds the Key to Stronger CAR T Cell Therapies, Review Argues
A Nature Reviews Cancer review argues that metabolism, from CAR design and manufacturing conditions to the patient's diet, is a ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
A Common Amino Acid Throws a Molecular Wrench Into the Body’s Inflammation Machine
New research shows the dietary amino acid l-arginine directly binds the NLRP3 inflammasome and blocks its assembly, easing inflammatory and ...
The Amino Acid Arginine Emerges as a Brake on the NLRP3 Inflammasome
A Nature Metabolism commentary highlights new evidence that the amino acid l-arginine can inhibit activation of the NLRP3 inflammasome, raising ...
Brain-Style NMDA Receptors Rewire Immune Cells Inside Tumors, Review Finds
A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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